Interaction of Germ Cells and Gonadal Somatic Cells During Gonadal Formation
The gonad is composed of many cell types, including germ cells. The different cell lineages likely associate with one another during formation of the gonadal primordium and during sex differentiation. However, the details of these interactions in the context of gonad formation and sex differentiation have not been clarified. Recently, cell tracing experiments in transgenic medaka and analysis of medaka mutants lacking expression of the type II Amh receptor (amhrII) have provided information about the cellular interactions between the several cell lineages in the gonad. Here, I give an overview of gonad development and discuss the role of Amh signaling during sex differentiation and maintenance of sex in the gonads.
KeywordsGerm Cell Granulosa Cell Theca Cell Female Gonad Male Gonad
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