TRP Channels and Mechanical Signals
Transient receptor potential (TRP) channels are a unique cellular mechanism converting a wide variety of signals, including mechanical stress, to cation flow. The protein was first discovered in studies that examined Drosophila phototransduction (Lo and Pak 1981). The photoreceptor cells of wild Drosophila exhibit sustained receptor potential, while a mutant showing a transient receptor potential (trp) in response to continuous light exposure was reported (Cosens and Manning 1969). The ionic basis for the sustained receptor potentials is an influx of Ca2+ from the extracellular space. The trp gene was cloned in 1989 (Montell and Rubin 1989) and was subsequently shown to encode a Ca2+-permeable cation channel (Hardie and Minke 1992). Since then, many channels that bear sequence and structural similarities to the Drosophila TRP have been cloned from flies, worms, and mammals.
KeywordsTransient Receptor Potential Primary Cilium Transient Receptor Potential Channel Mechanosensitive Channel Cortical Collect Duct
This work was supported by grants-in-aid for scientific research (17590255, 18590899, 22590291), and grants from Japan Space Forum, JAXA.
- Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389 : 816–824Google Scholar
- Corey DP, Garcia-Anoveros J, Holt JR, Kwan KY, Lin SY, Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Geleoc GS, Gray PA, Hoffman MP, Rehm HL, Tamasauskas D, Zhang DS (2004) TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 432 : 723–730PubMedCrossRefGoogle Scholar
- Dietrich A, Kalwa H, Storch U, Mederos Y, Schnitzler M, Salanova B, Pinkenburg O, Dubrovska G, Essin K, Gollasch M, Birnbaumer L, Gudermann T (2007) Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflugers Arch 455 : 465–477PubMedCrossRefGoogle Scholar
- Gavva NR, Klionsky L, Qu Y, Shi L, Tamir R, Edenson S, Zhang TJ, Viswanadhan VN, Toth A, Pearce LV, Vanderah TW, Porreca F, Blumberg PM, Lile J, Sun Y, Wild K, Louis JC, Treanor JJ (2004) Molecular determinants of vanilloid sensitivity in TRPV1. J Biol Chem 279 : 20283–20295PubMedCrossRefGoogle Scholar
- Huber TB, Schermer B, Muller RU, Hohne M, Bartram M, Calixto A, Hagmann H, Reinhardt C, Koos F, Kunzelmann K, Shirokova E, Krautwurst D, Harteneck C, Simons M, Pavenstadt H, Kerjaschki D, Thiele C, Walz G, Chalfie M, Benzing T (2006) Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci USA 103 : 17079–17086PubMedCrossRefGoogle Scholar
- Kottgen M, Buchholz B, Garcia-Gonzalez MA, Kotsis F, Fu X, Doerken M, Boehlke C, Steffl D, Tauber R, Wegierski T, Nitschke R, Suzuki M, Kramer-Zucker A, Germino GG, Watnick T, Prenen J, Nilius B, Kuehn EW, Walz G (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol 182 : 437–447PubMedCrossRefGoogle Scholar