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Mechanobiology in Skeletal Muscle: Conversion of Mechanical Information into Molecular Signal

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Mechanosensing Biology

Abstract

Overload leads to muscle hypertrophy. In the process, several events occur inside and outside the myofibers, including increased protein synthesis, change in gene expression, fiber-type transition, satellite cell activation, and angiogenesis (Bassel- Duby and Olson 2006; Blaauw et al. 2009). Interestingly, at the early phase of muscle hypertrophy, protein synthesis significantly increases (Baar et al. 2006), and later the transcription of growth-related genes follows (Carson 1997). Satellite cell activation is generally thought to be a critical component for increase in muscle mass; however, it is still a debated issue whether satellite cell incorporation into hypertrophying muscle fibers is required for muscle hypertrophy (O’Connor and Pavlath 2007; McCarthy and Esser 2007).

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Acknowledgment

The authors wish to thank members of the laboratory for discussion and critical readings.

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Authors and Affiliations

  1. Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan

    Yuko Miyagoe-Suzuki

  2. Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan

    Shin’ichi Takeda

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  1. Yuko Miyagoe-Suzuki
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  2. Shin’ichi Takeda
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Correspondence to Shin’ichi Takeda .

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  1. Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan

    Masaki Noda M.D., Ph.D. (Professor, Director) (Professor, Director)

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Miyagoe-Suzuki, Y., Takeda, S. (2011). Mechanobiology in Skeletal Muscle: Conversion of Mechanical Information into Molecular Signal. In: Noda, M. (eds) Mechanosensing Biology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-89757-6_4

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