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Expression of Rad21 Cleaved Products in Oral Epithelium

  • Conference paper
New Trends in the Molecular and Biological Basis for Clinical Oncology

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Abstract

Although RAD21 is involved in the repair of DNA double-strand breaks and is essential for mitotic growth, its role in cancer has been unclear. Recently, cleaved products of RAD21 by caspase 3 and 7 become a factor inducing apoptosis. And there are some reports about the association of tumor formation and RAD21. Our current study indicates the RAD21 gene was closely related to the invasion and metastasis of the cancer cells. In addition, although it is known that there are many cleavage products, about those functions, it is not clear. In this study, the relevance of RAD21 cleaved products expression to cell differentiation and carcinogenesis of oral squamous epithelium was clarified using Laser Microdissection and Western Blot analysis.

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Authors and Affiliations

  1. Department of Oral Pathology and Diagnosis, Showa University School of Dentistry, Hatanodai 1-5-8, Shinagawa-ku, Tokyo, 142-8555, Japan

    Gou Yamamoto, Taku Matsunaga, Tomohide Isobe, Tarou Irie & Tetsuhiko Tachikawa

Authors
  1. Gou Yamamoto
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  2. Taku Matsunaga
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  3. Tomohide Isobe
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  4. Tarou Irie
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  5. Tetsuhiko Tachikawa
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Editor information

Editors and Affiliations

  1. Department of Oral Pathology and Diagnosis, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Tetsuhiko Tachikawa D.D.S., Ph.D. (Professor and Chairman) (Professor and Chairman)

  2. Department of Microbiology, Showa University School of Pharmaceutical Sciences, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Kiyoshi Nose Ph.D. (Professor and Chairman) (Professor and Chairman)

  3. Institute of Molecular Oncology, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Tohru Ohmori M.D., Ph.D. (Associate Professor) (Associate Professor)

  4. Division of Allergology and Respiratory Medicine, Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan

    Mitsuru Adachi M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

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© 2009 Springer

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Yamamoto, G., Matsunaga, T., Isobe, T., Irie, T., Tachikawa, T. (2009). Expression of Rad21 Cleaved Products in Oral Epithelium. In: Tachikawa, T., Nose, K., Ohmori, T., Adachi, M. (eds) New Trends in the Molecular and Biological Basis for Clinical Oncology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-88663-1_17

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  • DOI: https://doi.org/10.1007/978-4-431-88663-1_17

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-88662-4

  • Online ISBN: 978-4-431-88663-1

  • eBook Packages: MedicineMedicine (R0)

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