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The Nonallergic Rhinitis of Chronic Fatigue Syndrome

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Allergy Frontiers: Clinical Manifestations

Part of the book series: Allergy Frontiers ((ALLERGY,volume 3))

Abstract

Chronic fatigue syndrome (CFS) is an enigmatic and often disputed illness. The initial cases were described as rapid onset fatigue with flu-like symptoms of malaise, myalgia and a sensation of feverishness that were detected in infection-like epidemiological clusters. Almost 74% of CFS subjects have nonallergic rhinitis of probable neurogenic origin. Other potential pathological mechanisms such as allergy, infection and immune deviation are unlikely to play causative roles. These subjects are likely to find their way into our offices making it imperative that we learn to recognize the condition and its allied syndromes, and develop an empathetic but structured approach to their long-term care.

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References

  1. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The International Chronic Fatigue Syndrome Study Group. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med 1994; 121:953–959.

    PubMed  CAS  Google Scholar 

  2. Reeves WC, Lloyd A, Vernon SD, Klimas N, Jason LA, Bleijenberg G, Evengard B, White PD, Nisenbaum R, Unger ER. International Chronic Fatigue Syndrome Study Group. Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution. BMC Health Serv Res 2003; 3:25.

    Article  PubMed  Google Scholar 

  3. Reeves WC, Wagner D, Nisenbaum R, Jones JF, Gurbaxani B, Solomon L, Papanicolaou DA, Unger ER, Vernon SD, Heim C. Chronic fatigue syndrome - a clinically empirical approach to its definition and study. BMC Med 2005; 3:19

    Article  PubMed  Google Scholar 

  4. Taylor RR, Jason LA. Chronic fatigue, abuse-related traumatization, and psychiatric disorders in a community-based sample. Soc Sci Med 2002; 55:247–256.

    Article  PubMed  Google Scholar 

  5. Cleveland CH, Jr., Fisher RH, Brestel EP, Esinhart JD, Metzger WJ. Chronic rhinitis: an under-recognized association with fibromyalgia. Allergy Proc 1992. Sept–Oct 1993; 13:263–267.

    Article  Google Scholar 

  6. Baraniuk JN, Clauw DJ, Gaumond E. Rhinitis symptoms in chronic fatigue syndrome. Ann Allergy Asthma Immunol 1998; 81:359–365.

    PubMed  CAS  Google Scholar 

  7. Baraniuk JN, Clauw D, Yuta A, Ali M, Gaumond E, Upadhyayula N, Fujita K, Shimizu T. Nasal secretion analysis in allergic rhinitis, cystic fibrosis, and nonallergic fibromyalgia/ chronic fatigue syndrome subjects. Am J Rhinol 1998; 12:435–440.

    Article  PubMed  CAS  Google Scholar 

  8. White KP, Speechley M, Harth M, Ostbye T. Co-existence of chronic fatigue syndrome with fibromyalgia syndrome in the general population. A controlled study. Scand J Rheumatol 2000; 29:44–51.

    Article  PubMed  CAS  Google Scholar 

  9. Baraniuk JN. Neurogenic inflammation. In: Leppert PC, Turned ML, eds. Vulvodynia: Toward Understanding a Pain Syndrome. Proceedings from the workshop April 14–15, 2003, supported by the National Institute of Child Health and Human Development (NICHD), the Office of Research on Women's Health, and the Office of Rare Diseases. pp. 16–18, 2004. http://www.nichd.nih.gov/publications/pubs/final_vulvodynia_report.pdf

  10. Baraniuk JN. CFS and overlapping conditions. CFS Res Rev 2004; 6–9.

    Google Scholar 

  11. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990; 33:160–172.

    Article  PubMed  CAS  Google Scholar 

  12. Petzke F, Ambrose K, Gracely RH, Clauw DJ. What do tender points measure? Arthritis Rheum 1999; 42:S342, abstr.

    Google Scholar 

  13. Gracely RH, Geisser ME, Giesecke T, Grant MA, Petzke F, Williams DA, Clauw DJ. Pain catastrophizing and neural responses to pain among persons with fibromyalgia. Brain 2004; 127:835–843.

    Article  PubMed  CAS  Google Scholar 

  14. Littlejohn GO. Balanced treatments for fibromyalgia. Arthritis Rheum 2004; 50:2725–2729.

    Article  PubMed  CAS  Google Scholar 

  15. Caterina MJ. Vanilloid receptors take a TRP beyond the sensory afferent. Pain 2003; 105:5–9.

    Article  PubMed  CAS  Google Scholar 

  16. Weidner C, Klede M, Rukwied R, Lischetzki G, Neisius U, Skov PS, Petersen LJ, Schmelz M. Acute effects of substance P and calcitonin gene-related peptide in human skin: a microdialysis study. J Invest Dermatol 2000; 115:1015–1020.

    Article  PubMed  CAS  Google Scholar 

  17. Naranch K, Park Y-J, Repka-Ramirez SM, Velarde A, Clauw D, Baraniuk JN. A tender sinus does not always mean sinusitis. Otolaryngol Head Neck Surg 2002; 127:387–397.

    Article  PubMed  CAS  Google Scholar 

  18. Baraniuk, JN, Naranch K, Maibach H, Clauw D. Tobacco sensitivity in Chronic Fatigue Syndrome. J CFS 2000; 7:33–52.

    Google Scholar 

  19. Baraniuk, JN, Naranch K, Maibach H, Clauw D. Irritant rhinitis in allergic, nonallergic, control and Chronic Fatigue Syndrome populations. J CFS 2000; 7:3–31.

    Google Scholar 

  20. Naranch K, Singer A, Gaumond E, Khine A, Velarde A, Clauw D, Baraniuk JN. Dyspnea in fibromyalgia (FM) and chronic fatigue syndrome (CFS). Am J Respir Crit Care Med 1999; 103:A763.

    Google Scholar 

  21. Straus SE, Dale JK, Wright R, Metcalfe DD. Allergy and chronic fatigue syndrome. J Allergy Clin Immunol 1988; 81:791–794.

    Article  PubMed  CAS  Google Scholar 

  22. Steinberg P, McNutt BE, Marshall P, Schenck C, Lurie N, Pheley A, Peterson PK. Double-blind placebo-controlled study of efficacy of oral terfenadine in the treatment of chronic fatigue syndrome. J Allergy Clin Immunol 1996; 97:119–126.

    Article  PubMed  CAS  Google Scholar 

  23. Gergen PJ, Turkeltaub PC, Kovar MG. The prevalence of allergic skin test reactivity to eight common aeroallergens in the U.S. population: results from the second National Health and Nutrition Examination Survey. J Allergy Clin Immunol 1987; 80:669.

    CAS  Google Scholar 

  24. Middleton E, Reed CE, Ellis EF, Adkinson NF, Yunginger JW, Busse WW. Allergy Principles and Practice. 4th edition. Mosby, St. Louis, MO, 1993.

    Google Scholar 

  25. Stjarne P, Lundblad L, Lundberg JM, Anggard A. Capsaicin and nicotine sensitive afferent neurones and nasal secretion in healthy human volunteers and in patients with vasomotor rhinitis. Br J Pharmacol 1989; 96:693–701.

    PubMed  CAS  Google Scholar 

  26. Mygind N, Naclerio RM, eds. Allergic and Nonallergic Rhinitis. WB Saunders, Philadelphia, PA, 1993.

    Google Scholar 

  27. Kakumanu SS, Mende CN, Lehman EB, Hughes K, Craig TJ. Effect of topical nasal corticosteroids on patients with chronic fatigue syndrome and rhinitis. J Am Osteopath Assoc 2003; 103:423–427.

    PubMed  Google Scholar 

  28. Wasserfallen JB, Gold K, Schulman KA, Baraniuk JN. Development and validation of a rhinoconjunctivitis and asthma symptom score for use as an outcome measure in clinical trials. J Allergy Clin Immunol 1997; 100:16–22.

    Article  PubMed  CAS  Google Scholar 

  29. Wasserfallen JB, Gold K, Schulman KA, Baraniuk JN. Item responsiveness of a rhinitis and asthma symptom score during a pollen season. J Asthma 1999; 36:459–465.

    Article  PubMed  CAS  Google Scholar 

  30. Repka-Ramirez MS, Naranch K, Park Y-J, Velarde A, Clauw D, Baraniuk JN. IgE levels are the same in Chronic Fatigue Syndrome (CFS) and control subjects when stratified by allergy skin test results and rhinitis types. Annals Allergy Asthma Immunol 2001; 87:218–221.

    CAS  Google Scholar 

  31. Manu P, Lane TJ, Matthews DA. The pathophysiology of chronic fatigue syndrome; confirmations, contradictions, and conjectures. Int J Psychiatry Med 1992; 22:397–408.

    PubMed  CAS  Google Scholar 

  32. Wray BB, Gaughf C, Chandler FW, Berry SS, Latham JE, Wood L, DuRant RH. Detection of Epstein-Barr virus and cytomegalovirus in patients with chronic fatigue. Ann Allergy 1993; 71:223–226.

    PubMed  CAS  Google Scholar 

  33. Straus SE. Studies of herpesvirus infection in chronic fatigue syndrome. Ciba Found Symp 1993; 173:132–197.

    PubMed  CAS  Google Scholar 

  34. Anonymous. Inability of retroviral tests to identify persons with chronic fatigue syndrome, 1992. MMWR 1993; 42:189–190.

    Google Scholar 

  35. Schulz R, Visintainer P, Williamson GM. Psychiatric and physical morbidity effects of caregiving. J Gerontol 1990; 45:181–191.

    Article  Google Scholar 

  36. Glaser R, MacCallum RC, Laskowski BF, Malarkey WB, Sheridan JF, Kiecolt-Glaser JK. Evidence for a shift in the Th-1 to Th-2 cytokine response associated with chronic stress and aging. J Gerontol A Biol Sci Med Sci 2001; 56:M477–M482.

    PubMed  CAS  Google Scholar 

  37. Baraniuk JN, Clauw D, Yuta A, Ali M, Gaumond E, Upadhyayula N, Fujita K, Shimizu T. Nasal secretion analysis in allergic rhinitis, cystic fibrosis, and nonallergic fibromyalgia/ chronic fatigue syndrome subjects. Am J Rhinol 1998; 12:435–440.

    Article  PubMed  CAS  Google Scholar 

  38. Yuta A, Ali M, Sabol M, Gaumond E, Baraniuk JN. Mucoglycoprotein hypersecretion in allergic rhinitis and cystic fibrosis. Am J Physiol 1997; 273 (Lung Cell Mol Physiol 17):L1203–L1207.

    PubMed  CAS  Google Scholar 

  39. Yuta A, van Deusen M, Gaumond E, Ali M, Baraniuk JN, Doyle W, Cohen S, Skoner D. Rhinovirus infection induces mucus hypersecretion. Am J Physiol 1998; 274 (Lung Cell Mol Physiol 18):L1017–L1023.

    PubMed  CAS  Google Scholar 

  40. Naranch K, Repka-Ramirez SM, Park Y-J, Velarde A, Finnegan R, Murray J, Pheiffer A, Hwang E, D Clauw, MD, JN Baraniuk. Differences in baseline nasal secretions between Chronic Fatigue Syndrome (CFS) and control subjects. J CFS 2002; 10:3–15.

    Google Scholar 

  41. Park Y-J, Repka-Ramirez SM, Naranch K, Velarde A, Clauw D, Baraniuk JN. Nasal lavage concentrations of free hemoglobin as a marker of microepistaxis during nasal provocation testing. Allergy 2002; 57:329–335.

    Article  PubMed  Google Scholar 

  42. Repka-Ramirez MS, Naranch K, Park Y-J, Clauw D, Baraniuk JN. Cytokines in nasal lavage fluids from acute sinusitis, allergic rhinitis, and Chronic Fatigue Syndrome subjects. Allergy Asthma Proc 2002; 23:185–190.

    PubMed  CAS  Google Scholar 

  43. Stein PK, Domitrovich PP, Ambrose K, Lyden A, Fine M, Gracely RH, Clauw DJ. Sex effects on heart rate variability in fibromyalgia and Gulf War illness. Arthritis Rheum 2004; 51:700–708.

    Article  PubMed  Google Scholar 

  44. Rowe PC, Bou-Holaigah I, Kan JS, Calkins H. Is neurally mediated hypotension an unrecognised cause of chronic fatigue? Lancet 1995; 345:623–624.

    Article  PubMed  CAS  Google Scholar 

  45. Qiao ZG, Vaerøy H, Mørkrid L. Electrodermal and microcirculatory activity in patients with fibromyalgia during baseline, acoustic stimulation and cold pressor tests. J Rheumatol 1991. Sept 1993; 18:1383–1389.

    PubMed  CAS  Google Scholar 

  46. Lynn R, Friedman L. Irritable bowel syndrome. N Engl J Med 1993; 329:1940–1945.

    Article  PubMed  CAS  Google Scholar 

  47. Buzzi M, Bonamini M, Cerbo R. The anatomy and biochemistry of headache. Funct Neurol 1993; 8:395–402.

    PubMed  CAS  Google Scholar 

  48. Pogacnik T, Sega S, Pecnik B, Kiauta T. Autonomic function testing in patients with migraine. Headache 1993; 33:545–550.

    Article  PubMed  CAS  Google Scholar 

  49. Appel S, Kuritzky A, Zahavi I, Zigelman M, Akselrod S. Evidence for instability of the autonomic nervous system in patients with migraine headache. Headache 1992; 32:10–17.

    Article  PubMed  CAS  Google Scholar 

  50. White AM, Stevens WH, Upton AR, et al. Airway responsiveness to inhaled methacholine in patients with irritable bowel syndrome. Gastroenterology 1991; 100:68–74.

    PubMed  CAS  Google Scholar 

  51. Whorwell PJ, Clouter C, Smith CL. Oesophageal motility in the irritable bowel syndrome. Br Med J 1981; 282:1101–1102.

    Article  CAS  Google Scholar 

  52. Whorwell PJ, Lupton EW, Erduran D, et al. Bladder smooth muscle dysfunction in patients with irritable bowel syndrome. Gut 1986; 27:1014–1017.

    Article  PubMed  CAS  Google Scholar 

  53. Adam V. Visceral Perception. Understanding Internal Cognition. Plenum, New York, 1998. pp. 1–232.

    Google Scholar 

  54. Chrousos GP, Gold PW. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 1992; 267:1244–1252.

    CAS  Google Scholar 

  55. Griep EN, Boersma JW, de Kloet ER. Altered reactivity of the hypothalamic-pituitary-adrenal axis in the primary fibromyalgia syndrome. J Rheumatol 1993; 20:469–474.

    PubMed  CAS  Google Scholar 

  56. van Denderen JC, Boersma JW, Zeinstra P, et al. Physiological effects of exhaustive physical exercise in primary fibromyalgia syndrome (PFS): is PFS a disorder of neuroendocrine reactivity? Scand J Rheumatol 1993; 21:35–37.

    Article  Google Scholar 

  57. Wilde AD, Cook JA, Jones AS. The nasal response to isometric exercise in non-eosinophilic intrinsic rhinitis. Clin Otolaryngol 1996; 21:84–86.

    Article  PubMed  CAS  Google Scholar 

  58. Park Y-J, Naranch K, Repka-Ramirez SM, Clauw D, Baraniuk JN. Sympathetic dysfunction demonstrated by isometric handgrip responses in CFS. American Association for Chronic Fatigue Syndrome. Seattle, WA (oral presentation), Jan 2001.

    Google Scholar 

  59. Baraniuk JN, Ali M, Naranch K. Hypertonic saline nasal provocation and acoustic rhinometry. Clin Exp Allergy 2002; 32:543–550.

    Article  PubMed  CAS  Google Scholar 

  60. Kurian SS, Blank MA, Sheppard MN. Vasoactive intestinal polypeptide (VIP) in vasomotor rhinitis. Clin Biochem 1983; 11:425–427.

    Google Scholar 

  61. Togias A, Lykens K, Kagey-Sobotka A, Eggleston PA, Proud D, Lichtenstein LM, Naclerio RM. Studies on the relationships between sensitivity to cold, dry air, hyperosmolar solutions, and histamine in the adult nose. Am Rev Respir Dis 1990; 141:1428–1433.

    PubMed  CAS  Google Scholar 

  62. Sanico AM, Philip G, Proud D, Naclerio RM, Togias A. Comparison of nasal mucosal responsiveness to neuronal stimulation in non-allergic and allergic rhinitis: effects of capsaicin nasal challenge. Clin Exp Allergy 1998; 28:92–100.

    Article  PubMed  CAS  Google Scholar 

  63. Liedtke W, Tobin DM, Bargmann CL, Friedman JM. Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. PNAS 2003; 100:14531–14536.

    Article  PubMed  CAS  Google Scholar 

  64. Baraniuk JN, Bolick M, Esch R, Buckley CE. Quantification of pollen solute release using pollen grain column chromatography. Allergy 1992; 47:411–417.

    Article  PubMed  CAS  Google Scholar 

  65. Peterson B, Saxon A. Global increases in allergic respiratory disease: the possible role of diesel exhaust particles. Ann Allergy Asthma Immunol 1996; 77:263–268.

    Article  PubMed  CAS  Google Scholar 

  66. Baraniuk JN, Petrie KN, Le U, Tai C-F, Park Y-J, Yuta A, Ali M, VandenBussche CJ, Nelson B. Neuropathology in rhinosinusitis. Am J Respir Crit Care Med 2005; 171:5–11.

    Article  PubMed  Google Scholar 

  67. Baraniuk JN, Ali M, Yuta A, Fang SY, Naranch K. Hypertonic saline nasal provocation stimulates nociceptive nerves, substance P release, and glandular mucous exocytosis in normal humans. Am J Respir Crit Care Med 1999; 160:655–662.

    PubMed  CAS  Google Scholar 

  68. Dray A, Urban L, Dickenson A. Pharmacology of chronic pain. TiPS 1994; 15:190–197.

    PubMed  CAS  Google Scholar 

  69. Raine R, Carter S, Sensky T, Black N. General practitioners' perceptions of chronic fatigue syndrome and beliefs about its management, compared with irritable bowel syndrome: qualitative study. BMJ 2004; 328:1354–1357.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Rheumatology, Immunology and Allergy, Georgetown University, Washington DC, USA

    James N. Baraniuk & Samantha Jean Merck

  2. Room B-105, Lower Level Kober-Cogan Building, 3800 Reservoir Road, NW, Washington DC, 20007–2197, USA

    James N. Baraniuk

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  1. James N. Baraniuk
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Editors and Affiliations

  1. Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan

    Ruby Pawankar

  2. Southampton General Hospital, University of Southampton, Tremona Road, Southampton, UK

    Stephen T. Holgate

  3. Childrens's Mercy Hospital and Clinic, UMKC School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA

    Lanny J. Rosenwasser

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Baraniuk, J.N., Merck, S.J. (2009). The Nonallergic Rhinitis of Chronic Fatigue Syndrome. In: Pawankar, R., Holgate, S.T., Rosenwasser, L.J. (eds) Allergy Frontiers: Clinical Manifestations. Allergy Frontiers, vol 3. Springer, Tokyo. https://doi.org/10.1007/978-4-431-88317-3_5

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  • DOI: https://doi.org/10.1007/978-4-431-88317-3_5

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