Latex Allergy: Clinical Manifestations

  • Kevin J. Kelly
  • Brian T. Kelly
Part of the Allergy Frontiers book series (ALLERGY, volume 3)


Latex allergy is one of the most interesting allergic diseases to present in the past two decades. It emerged explosively in the late 1980’s with rapid and widespread clinical problems for patients with neural tube defects, multiple surgeries, healthcare workers and others. It appears to be the one disease that is a consequence of medical recommendations (Universal precautions) made to prevent the spread of viral disease in humans such as hepatitis and Human Immunodeficiency Virus (HIV). Those recommendations led to a massive increase in the use of latex gloves with high allergen content that may have resulted in the sensitization and symptoms of IgE mediated diseases such as urticaria, angioedema, anaphylaxis, cross-reactive food allergy, and occupational asthma. Manufacturing changes in gloves, scientific advances in understanding of the disease prevention, litigation, and emergence of newer substitute materials that replace natural rubber latex have seen a quelling of the disease. However, those already allergically sensitized and those individuals working in industries where glove use is relatively unregulated (e.g. food handlers) seem to still be at risk. This chapter summarizes the major clinical manifestations of latex allergy.


Health Care Worker Natural Rubber Allergy Clin Immunol Spina Bifida Occupational Asthma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2009

Authors and Affiliations

  • Kevin J. Kelly
    • 1
  • Brian T. Kelly
    • 2
  1. 1.Joyce C. Hall Distinguished Professor of Pediatrics, Chairman – Department of Pediatrics, Children's Mercy Hospitals & ClinicsAssociate Dean – University of Missouri Kansas City School of MedicineKansas CityUSA
  2. 2.Kansas City School of MedicineB.T. Kelly University of MissouriKansas CityUSA

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