Mechanisms of Anaphylaxis

  • Stephen F. Kemp
  • Richard F. Lockey
Part of the Allergy Frontiers book series (ALLERGY, volume 3)


Anaphylaxis is a life-threatening syndrome resulting from the sudden release of mast cell- and basophil-derived mediators into the circulation. Foods and medications cause most anaphylaxis for which a cause can be identified, but virtually any agent capable of directly or indirectly activating mast cells or basophils can cause this syndrome. This review discusses the pathophysiologic mechanisms of anaphylaxis.


Mast Cell Platelet Activate Factor Allergy Clin Immunol Anaphylactic Shock World Allergy Organization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2009

Authors and Affiliations

  • Stephen F. Kemp
    • 1
  • Richard F. Lockey
    • 2
  1. 1.Division of Clinical Immunology and Allergy, Department of MedicineThe University of Mississippi Medical CenterJacksonUSA
  2. 2.Division of Allergy and Immunology, Department of Internal MedicineUniversity of South Florida College of Medicine and the James A. Haley Veterans Administration HospitalTampaUSA

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