Allergic Bronchopulmonary Aspergillosis

  • Viswanath P. Kurup
  • Alan P. Knutsen
Part of the Allergy Frontiers book series (ALLERGY, volume 3)


ABPA is an important hypersensitivity disease associated with asthma and cystic fibrosis, resulting from exposure to Aspergillus. ABPA patients show elevated serum Ig E and Aspergillus -specific IgE, IgG and IgA antibodies in their sera. Peripheral blood eosinophilia, airway hyper reactivity and inflammatory responses to Aspergillus antigens are characteristic features in ABPA. Important allergens and antigens of A. fumigatus have been cloned, expressed and characterized. Diagnostic values of some of these cloned antigens have been ascertained by immunological assays. Epitopes of the relevant antigens that have potential role in immunotherapy have been identified. Our current knowledge on the immunopathogenesis and the genetical predisposition of ABPA has been discussed. We have also presented information on the diagnostic, immunologic, epidemiologic and pharmacotherapeutic aspects of ABPA.


Cystic Fibrosis Allergy Clin Immunol Pulmonary Infiltrate Allergic Bronchopulmonary Aspergillosis Research Signpost 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2009

Authors and Affiliations

  • Viswanath P. Kurup
    • 1
  • Alan P. Knutsen
    • 2
  1. 1.Department of Pediatrics, Medical College of WisconsinAsthma and Allergy CenterMilwaukeeUSA
  2. 2.A.P. Knutsen Pediatrics Research InstituteSt. Louis University Health SciencesSt. LouisUSA

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