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Non-atopic Asthma: A Continuing Enigma

  • Chris Corrigan
Part of the Allergy Frontiers book series (ALLERGY, volume 3)

Despite large inroads into understanding the comparative pathology of atopic and non-atopic asthma in the past decade, and appreciation that the airways mucosa is a key site of IgE synthesis, and that such synthesis may not always be detectable peripherally and not always directed against conventional “aeroallergens”, non-atopic asthma remains an enigma. A working hypothesis of mechanisms of intrinsic asthma, built around the possible roles of IgE is presented in Fig. 1. In terms of the bronchial mucosal cellular infiltrate and local expression of cytokines and chemokines that are thought to be important in disease pathogenesis, atopic and non-atopic asthma are very similar diseases.

Keywords

Allergy Clin Immunol Bronchial Hyperresponsiveness Bronchial Mucosa Respiratory Mucosa Asthma Pathogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2009

Authors and Affiliations

  • Chris Corrigan
    • 1
  1. 1.Department of Asthma, Allergy Respiratory Science and MRC and Asthma UK Centre for Allergic Mechanisms of AsthmaProfessor of Asthma, Allergy and Respiratory Science, King's College London School of MedicineLondonUK

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