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Non-atopic Asthma: A Continuing Enigma

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Allergy Frontiers: Clinical Manifestations

Part of the book series: Allergy Frontiers ((ALLERGY,volume 3))

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Despite large inroads into understanding the comparative pathology of atopic and non-atopic asthma in the past decade, and appreciation that the airways mucosa is a key site of IgE synthesis, and that such synthesis may not always be detectable peripherally and not always directed against conventional “aeroallergens”, non-atopic asthma remains an enigma. A working hypothesis of mechanisms of intrinsic asthma, built around the possible roles of IgE is presented in Fig. 1. In terms of the bronchial mucosal cellular infiltrate and local expression of cytokines and chemokines that are thought to be important in disease pathogenesis, atopic and non-atopic asthma are very similar diseases.

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Author information

Authors and Affiliations

  1. Department of Asthma, Allergy Respiratory Science and MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, Professor of Asthma, Allergy and Respiratory Science, King's College London School of Medicine, 5th Floor, Tower Wing, Guy's Hospital, London, SE1 9RT, UK

    Chris Corrigan

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  1. Chris Corrigan
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Editors and Affiliations

  1. Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan

    Ruby Pawankar

  2. Southampton General Hospital, University of Southampton, Tremona Road, Southampton, UK

    Stephen T. Holgate

  3. Childrens's Mercy Hospital and Clinic, UMKC School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA

    Lanny J. Rosenwasser

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© 2009 Springer

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Corrigan, C. (2009). Non-atopic Asthma: A Continuing Enigma. In: Pawankar, R., Holgate, S.T., Rosenwasser, L.J. (eds) Allergy Frontiers: Clinical Manifestations. Allergy Frontiers, vol 3. Springer, Tokyo. https://doi.org/10.1007/978-4-431-88317-3_20

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  • DOI: https://doi.org/10.1007/978-4-431-88317-3_20

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-88316-6

  • Online ISBN: 978-4-431-88317-3

  • eBook Packages: MedicineMedicine (R0)

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