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Mechanisms of Mucus Induction in Asthma

  • Lauren Cohn
Part of the Allergy Frontiers book series (ALLERGY, volume 3)

Abstract

Mucus hypersecretion is a defining feature of asthma and contributes significantly to airway obstruction. The mechanisms by which a normal airway epithelium is converted to a mucus-producing epithelium in asthma are complex. Inflammation in asthma promotes metaplasia of ciliated and Clara cells into goblet cells after both EGFR activation and the effects of IL-13 on Stat6 activation. Recently identified transcription factors and proteins highlight critical steps in the pathway that leads to the transition to a mucus-secreting airway epithelium.

Keywords

Epidermal Growth Factor Receptor Goblet Cell Airway Epithelial Cell Clara Cell Airway Hyperreactivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2009

Authors and Affiliations

  • Lauren Cohn
    • 1
  1. 1.Section of Pulmonary and Critical Care MedicineYale University School of MedicineNew HavenUSA

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