Abstract
Mucosal surfaces, including those of the respiratory and gastrointestinal tracts, are continuously exposed to numerous kinds of environmental antigens and allergens and to the risk of invasion by pathogens. The mucosal immune system thus provides the first line of defense against mucosally encountered pathogens and allergens. It also serves an important role in the development of cohabitation by commensal flora and nutrient antigens, thereby facilitating the development of an appropriate immunological response and physiological homeostasis between the host and its outside environment. For the execution of these dynamic immune responses in the aerodigestive tract, mucosa-associated lymphoid tissue (MALT), which consists of nasopharynx-associated lymphoid tissue (NALT), bronchus-associated lymphoid tissue (BALT), and gut-associated lymphoid tissue (GALT), has been shown to be an important site for the induction of antigen-specific immune responses in both the mucosal and systemic compartments of immunity. Mucosal tolerance initiated in these inductive tissues is also necessary for the prevention or control of harmful immune responses against inhaled airborne antigens and ingested food antigens. Disruption of the induction of mucosal tolerance is one of the factors that contribute to the development of allergic disease. Thus, the elucidation and understanding of the molecular and cellular uniqueness of the mucosal immune system is necessary for the prevention and control of hyperallergic responses and thus the maintenance of healthy functioning. The emphasis of this chapter is on the introduction of dynamism in MALT organogenesis as well as the functional role of these inductive tissues within the mucosal immune system.
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References
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Fukuyama, S., Nagatake, T., Kiyono, H. (2009). Mucosa-Associated Lymphoid Tissue and Dynamics of Lymphoid Cells in the Five Different Compartments in Allergic Diseases. In: Pawankar, R., Holgate, S.T., Rosenwasser, L.J. (eds) Allergy Frontiers: Classification and Pathomechanisms. Allergy Frontiers, vol 2. Springer, Tokyo. https://doi.org/10.1007/978-4-431-88315-9_32
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