Allergy and the Bone Marrow: Transmigration Pathways of Hemopoietic Progenitor Cells from the Bone Marrow

  • Roma Sehmi
  • Jennifer V. Thomson
  • Adriana Catalli
Part of the Allergy Frontiers book series (ALLERGY, volume 2)

Allergic airways diseases are a leading cause of morbidity and mortality both in Canada and globally, and as such, highlight the pressing need for effective pharmacotherapy to adequately control these conditions. Asthma is a chronic inflammatory disease characterized by variable bronchial obstruction, airway hyperresponsiveness (AHR) and infiltration of the airways by activated pro-inflammatory cells, predominantly eosinophils implicated as prime effector cells of the pulmonary pathology of asthma. Novel anti-eosinophil therapies such as interleukin-5 (IL-5) blocking antibodies have proven largely unsuccessful in ameliorating critical symptoms of asthma including AHR, thus emphasizing the need to understand the broader scope of the asthmatic response and the multifactorial nature of this disease…


Allergy Clin Immunol Respir Crit CXCR4 Expression Allergen Challenge Allergic Inflammation 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Roma Sehmi
    • 1
  • Jennifer V. Thomson
    • 1
  • Adriana Catalli
    • 1
  1. 1.Firestone Institute of Respiratory Health, Asthma Research Group, St. Joseph's Healthcare, Department of MedicineMcMaster UniversityHamiltonCanada

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