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Airway Smooth Muscle Dysfunction in Asthma

  • Maria B. Sukkar
  • Kian Fan Chung
Part of the Allergy Frontiers book series (ALLERGY, volume 2)

Asthma is characterised by intermittent airflow obstruction with excessive bronchoconstriction and bronchial hyperresponsiveness (BHR). Since the airway smooth muscle (ASM) is the main contractile cell of the airways, it is clear that the ASM plays a major role in the genesis of these abnormalities. Airflow obstruction does not usually occur in non-asthmatics, thus one would presume that the ASM is abnormally contractile in asthma and there is now evidence that the abnormality of the contractile apparatus can be demonstrated in the asthmatic ASM itself. Therapies to relieve airflow obstruction promptly such as the inhalation of 2-adrenergic agonists are directly aimed at the ASM.

Keywords

Connective Tissue Growth Factor Airway Smooth Muscle Allergy Clin Immunol Respir Crit Airway Smooth Muscle Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Maria B. Sukkar
    • 1
  • Kian Fan Chung
    • 1
  1. 1.Airway Disease Section, National Heart and Lung InstituteImperial College LondonLondonUK

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