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Adenosine: Its Contribution to Our Understanding in Airway Inflammation

  • Riccardo Polosa
Part of the Allergy Frontiers book series (ALLERGY, volume 2)

Summary

Growing evidence emphasizes that the purine nucleoside adenosine plays an active role as local regulator in airway inflammation and pulmonary diseases. The notion that increased adenosine concentrations are associated with lung inflammation indicates the importance of this signaling pathway, which involves the activation of a family of cell surface G-protein coupled receptor subtypes named as A1, A2A, A2B and A3. These can be identified on a large variety of inflammatory structural cell types with known relevance to the pathogenesis of chronic inflammatory disorders of the airways such as asthma and chronic obstructive pulmonary disease (COPD). As a consequence, new molecules with high affinity and high selectivity for the human adenosine receptors subtypes designed to control the airway inflammatory component of asthma have been launched and are currently tested in clinical trials as anti-asthma treatments. In addition, an important development is the use of adenosine (or AMP) as a diagnostic test for discriminating asthma from COPD, and as an accurate biomarker to monitor corticosteroid requirements in asthma. It is likely that therapies interfering with adenosine signalling in the airways and the availability of adenosine-based diagnostic tests will offer a considerable advance in the management of asthma and COPD.

Keywords

Mast Cell Airway Inflammation Adenosine Receptor Allergy Clin Immunol Exhale Breath Condensate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Riccardo Polosa
    • 1
  1. 1.Director, Institute of Internal Medicine and Clinical Immunology, S. Marta HospitalUniversity of CataniaCataniaItaly

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