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The Role of Platelets in Allergy

  • Kristin N. Kornerup
  • Clive P. Page
Part of the Allergy Frontiers book series (ALLERGY, volume 2)

Abstract

In addition to their role in haemostasis and thrombosis, platelets are now known to actively participate in both allergic and non-allergic types of inflammation. Within the area of allergic disorders, including airway and cutaneous conditions, substantial clinical and experimental evidence is accumulating suggesting an important role for platelets in their pathophysiology. Taken together, the studies indicate that both the presence of functional, intact platelets and the release of inflammatory mediators from platelets are crucial events for a sustained allergic inflammatory response. Although the data currently available are convincing, further studies, especially larger clinical ones, are needed to cement the role of platelets in allergy and, thus, hopefully engender a search for novel therapies that will selectively target the pro-inflammatory functions of platelets while leaving their haemostatic functions unaffected.

Keywords

Atopic Dermatitis Allergy Clin Immunol Leukocyte Recruitment Glyceryl Ether Follow Allergen Challenge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Kristin N. Kornerup
    • 1
  • Clive P. Page
    • 1
  1. 1.Sackler Institute of Pulmonary Pharmacology and TherapeuticsSchool of Biomedical and Health Sciences, King's College LondonLondonUK

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