The Role of Platelets in Allergy

  • Kristin N. Kornerup
  • Clive P. Page
Part of the Allergy Frontiers book series (ALLERGY, volume 2)


In addition to their role in haemostasis and thrombosis, platelets are now known to actively participate in both allergic and non-allergic types of inflammation. Within the area of allergic disorders, including airway and cutaneous conditions, substantial clinical and experimental evidence is accumulating suggesting an important role for platelets in their pathophysiology. Taken together, the studies indicate that both the presence of functional, intact platelets and the release of inflammatory mediators from platelets are crucial events for a sustained allergic inflammatory response. Although the data currently available are convincing, further studies, especially larger clinical ones, are needed to cement the role of platelets in allergy and, thus, hopefully engender a search for novel therapies that will selectively target the pro-inflammatory functions of platelets while leaving their haemostatic functions unaffected.


Atopic Dermatitis Allergy Clin Immunol Leukocyte Recruitment Glyceryl Ether Follow Allergen Challenge 
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  1. 1.
    Mannaioni PF, Di Bello MG, Masini E (1997) Platelets and inflammation: role of platelet-derived growth factor, adhesion molecules and histamine. Inflamm Res 46(1):4–18PubMedCrossRefGoogle Scholar
  2. 2.
    Gawaz M (2003) Do platelets trigger atherosclerosis? Thromb Haemost 90(6):971–972PubMedGoogle Scholar
  3. 3.
    Schmitt-Sody M, Klose A, Gottschalk O, Metz P, Gebhard H, Zysk S, Eichhorn ME, Hernandez-Richter TM, Jansson V, Veihelmann A (2005) Platelet-endothelial cell interactions in murine antigen-induced arthritis. Rheumatology (Oxford) 44(7):885–889CrossRefGoogle Scholar
  4. 4.
    Arisato T, Hashiguchi T, Sarker KP, Arimura K, Asano M, Matsuo K, Osame M, Maruyama I (2003) Highly accumulated platelet vascular endothelial growth factor in coagulant throm-botic region. J Thromb Haemost 1(12):2589–2593PubMedCrossRefGoogle Scholar
  5. 5.
    Banks RE, Forbes MA, Kinsey SE, Stanley A, Ingham E, Walters C, Selby PJ (1998) Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets:significance for VEGF measurements and cancer biology. Brit J Cancer 77(6):956–964PubMedGoogle Scholar
  6. 6.
    Rocca B, Bellacosa A, De Cristofaro R, Neri G, Della Ventura M, Maggiano N, Rumi C, Landolfi R (1996) Wiskott-Aldrich syndrome:report of an autosomal dominant variant. Blood 87(11):4538–4543PubMedGoogle Scholar
  7. 7.
    Mori S, Fujieda S, Sunaga H, Fox SB, Saito H (2000) Expression of platelet-derived endothe-lial cell growth factor and vascularity in the nasal mucosa from allergic rhinitis. Clin Exp Allergy 30(11):1637–1644PubMedCrossRefGoogle Scholar
  8. 8.
    Ring J, Allen DH, Mathison DA, Spiegelberg HL (1980) In vitro releasability of histamine and serotonin:studies of atopic patients. J Clin Lab Immunol 3(2):85–91PubMedGoogle Scholar
  9. 9.
    Herd CM, Page CP (1994) Pulmonary immune cells in health and disease:platelets. Eur Respir J 7(6):1145–1160PubMedGoogle Scholar
  10. 10.
    Herzberg MC, Brintzenhofe KL, Clawson CC (1983) Aggregation of human platelets and adhesion of Streptococcus sanguis. Infect Immun 39(3):1457–1469PubMedGoogle Scholar
  11. 11.
    Clark SR, Ma AC, Tavener SA, McDonald B, Goodarzi Z, Kelly MM, Patel KD, Chakrabarti S, McAvoy E, Sinclair GD, Keys EM, Allen-Vercoe E, Devinney R, Doig CJ, Green FH, Kubes P (2007) Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 13(4):463–469PubMedCrossRefGoogle Scholar
  12. 12.
    Yeo EL, Sheppard JA, Feuerstein IA (1994) Role of P-selectin and leukocyte activation in polymorphonuclear cell adhesion to surface adherent activated platelets under physiologic shear conditions (an injury vessel wall model). Blood 83(9):2498–2507PubMedGoogle Scholar
  13. 13.
    Kuijper PH, Gallardo Torres HI, van der Linden JA, Lammers JW, Sixma JJ, Koenderman L, Zwaginga JJ (1996) Platelet-dependent primary hemostasis promotes selectin- and integrin-mediated neutrophil adhesion to damaged endothelium under flow conditions. Blood 87(8):3271–3281PubMedGoogle Scholar
  14. 14.
    Sheikh S, Nash GB (1996) Continuous activation and deactivation of integrin CD11b/CD18 during de novo expression enables rolling neutrophils to immobilize on platelets. Blood 87(12):5040–5050PubMedGoogle Scholar
  15. 15.
    Weber C, Springer TA (1997) Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. J Clin Invest 100(8):2085–2093PubMedCrossRefGoogle Scholar
  16. 16.
    Evangelista V, Manarini S, Sideri R, Rotondo S, Martelli N, Piccoli A, Totani L, Piccardoni P, Vestweber D, de Gaetano G, Cerletti C (1999) Platelet/polymorphonuclear leukocyte interaction:P-selectin triggers protein-tyrosine phosphorylation-dependent CD11b/CD18 adhesion:role of PSGL-1 as a signaling molecule. Blood 93(3):876–885PubMedGoogle Scholar
  17. 17.
    Diacovo TG, Roth SJ, Buccola JM, Bainton DF, Springer TA (1996) Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18. Blood 88(1):146–157PubMedGoogle Scholar
  18. 18.
    Palabrica T, Lobb R, Furie BC, Aronovitz M, Benjamin C, Hsu YM, Sajer SA, Furie B (1992) Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature 359(6398):848–851PubMedCrossRefGoogle Scholar
  19. 19.
    Pitchford SC, Momi S, Giannini S, Casali L, Spina D, Page CP, Gresele P (2005) Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation. Blood 105(5):2074–2081PubMedCrossRefGoogle Scholar
  20. 20.
    Taytard A, Guenard H, Vuillemin L, Bouvot JL, Vergeret J, Ducassou D, Piquet Y, Freour P (1986) Platelet kinetics in stable atopic asthmatic patients. Am Rev Respir Dis 134(5):983–985PubMedGoogle Scholar
  21. 21.
    Szczeklik A, Milner PC, Birch J, Watkins J, Martin JF (1986) Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. Thromb Haemost 56(3):283–287PubMedGoogle Scholar
  22. 22.
    Szczeklik A, Krzanowski M, Nizankowska E, Musial J (1987) Bleeding time and PAF-acether-induced platelet aggregation in atopy. Agents Actions Suppl 21:145–150PubMedCrossRefGoogle Scholar
  23. 23.
    Gresele P, Dottorini M, Selli ML, Iannacci L, Canino S, Todisco T, Romano S, Crook P, Page CP, Nenci GG (1993) Altered platelet function associated with the bronchial hyper-responsiveness accompanying nocturnal asthma. J Allergy Clin Immunol 91(4):894–902PubMedCrossRefGoogle Scholar
  24. 24.
    Maccia CA, Gallagher JS, Ataman G, Glueck HI, Brooks SM, Bernstein IL (1977) Platelet thrombopathy in asthmatic patients with elevated immunoglobulin E. J Allergy Clin Immunol 59:101–108PubMedCrossRefGoogle Scholar
  25. 25.
    Beer JH, Wuthrich B, von Felten A (1995) Allergen exposure in acute asthma causes the release of platelet-activating factor (PAF) as demonstrated by the desensitization of platelets to PAF. Int Arch Allergy Immunol 106(3):291–296PubMedCrossRefGoogle Scholar
  26. 26.
    Rogala B, Gumprecht J, Glueck J (1999) Platelet aggregation in atopic dermatitis. Platelets 10(5):341–344PubMedCrossRefGoogle Scholar
  27. 27.
    Hilger RA, Neuber K, Konig W (1991) Conversion of leukotriene A4 by neutrophils and platelets from patients with atopic dermatitis. Immunology 74(4):689–695PubMedGoogle Scholar
  28. 28.
    Maestrelli P, Boschetto P, Zocca E, Crescioli S, Baroldi P, Mapp C, Fabbri LM (1990) Venous blood platelets decrease during allergen-induced asthmatic reactions. Clin Exp Allergy 20(4):367–372PubMedCrossRefGoogle Scholar
  29. 29.
    Sullivan PJ, Jafar ZH, Harbinson PL, Restrick LJ, Costello JF, Page CP (2000) Platelet dynamics following allergen challenge in allergic asthmatics. Respiration 67(5):514–517PubMedCrossRefGoogle Scholar
  30. 30.
    Kowal K, Pampuch A, Kowal-Bielecka O, DuBuske LM, Bodzenta-Lukaszyk A (2006) Platelet activation in allergic asthma patients during allergen challenge with Dermatophagoides pteronyssinus. Clin Exp Allergy 36(4):426–432PubMedCrossRefGoogle Scholar
  31. 31.
    Beasley R, Roche WR, Roberts JA, Holgate ST (1989) Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 139(3):806–817PubMedGoogle Scholar
  32. 32.
    Gresele P, Todisco T, Merante F, Nenci GG (1982) Platelet activation and allergic asthma. New Engl J Med 306(9):549PubMedGoogle Scholar
  33. 33.
    Ind PW, Peters AM, Malik F, Lavender JP, Dollery CT (1985) Pulmonary platelet kinetics in asthma. Thorax 40(6):412–417PubMedCrossRefGoogle Scholar
  34. 34.
    Hemmendinger S, Pauli G, Tenabene A, Pujol JL, Bessot JC, Eber M, Cazenave JP (1989) Platelet function:aggregation by PAF or sequestration in lung is not modified during immediate or late allergen-induced bronchospasm in man. J Allergy Clin Immunol 83(5):990–996PubMedCrossRefGoogle Scholar
  35. 35.
    Yamamoto H, Nagata M, Tabe K, Kimura I, Kiuchi H, Sakamoto Y, Yamamoto K, Dohi Y (1993) The evidence of platelet activation in bronchial asthma. J Allergy Clin Immunol 91 (1 Pt 1):79–87PubMedCrossRefGoogle Scholar
  36. 36.
    Chihara J, Yasuba H, Tsuda A, Urayama O, Saito N, Honda K, Kayaba H, Yamashita T, Kurimoto F, Yamada H (1997) Elevation of the plasma level of RANTES during asthma attacks. J Allergy Clin Immunol 100(6 Pt 2):S52–5PubMedCrossRefGoogle Scholar
  37. 37.
    Knauer KA, Fish JE, Adkinson NF, Jr, Lichtenstein LM, Peters SP, Newball HH (1981) Platelet activation in antigen-induced bronchoconstriction. New Engl J Med 305(15):892–893PubMedCrossRefGoogle Scholar
  38. 38.
    Averill FJ, Hubbard WC, Proud D, Gleich GJ, Liu MC (1992) Platelet activation in the lung after antigen challenge in a model of allergic asthma. Am Rev Respir Dis 145(3):571–576PubMedGoogle Scholar
  39. 39.
    Kasperska-Zajac A, Nowakowski M, Rogala B (2004) Enhanced platelet activation in patients with atopic eczema/dermatitis syndrome. Inflammation 28(5):299–302CrossRefPubMedGoogle Scholar
  40. 40.
    Hasegawa S, Tashiro N, Matsubara T, Furukawa S, Ra C (2001) A comparison of FcepsilonRI-mediated RANTES release from human platelets between allergic patients and healthy individuals. Int Arch Allergy Immunol 125 Suppl 1:42–47PubMedCrossRefGoogle Scholar
  41. 41.
    Fujisawa T, Fujisawa R, Kato Y, Nakayama T, Morita A, Katsumata H, Nishimori H, Iguchi K, Kamiya H, Gray PW, Chantry D, Suzuki R, Yoshie O (2002) Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis. J Allergy Clin Immunol 110(1):139–146PubMedCrossRefGoogle Scholar
  42. 42.
    Joseph M, Capron A, Ameisen JC, Capron M, Vorng H, Pancre V, Kusnierz JP, Auriault C (1986) The receptor for IgE on blood platelets. Eur J Immunol 16(3):306–312PubMedCrossRefGoogle Scholar
  43. 43.
    King M, McDermott P, Schreiber AD (1990) Characterization of the Fc gamma receptor on human platelets. Cell Immunol 128(2):462–479PubMedCrossRefGoogle Scholar
  44. 44.
    Tomiyama Y, Kunicki TJ, Zipf TF, Ford SB, Aster RH (1992) Response of human platelets to activating monoclonal antibodies:importance of Fc gamma RII (CD32) phenotype and level of expression. Blood 80(9):2261–2268PubMedGoogle Scholar
  45. 45.
    Hasegawa S, Pawankar R, Suzuki K, Nakahata T, Furukawa S, Okumura K, Ra C (1999) Functional expression of the high affinity receptor for IgE (FcepsilonRI) in human platelets and its' intracellular expression in human megakaryocytes. Blood 93(8):2543–2551PubMedGoogle Scholar
  46. 46.
    Klouche M, Klinger MH, Kuhnel W, Wilhelm D (1997) Endocytosis, storage, and release of IgE by human platelets:differences in patients with type I allergy and nonatopic subjects. J Allergy Clin Immunol 100(2):235–241PubMedCrossRefGoogle Scholar
  47. 47.
    Pinckard RN, Halonen M, Palmer JD, Butler C, Shaw JO, Henson PM (1977) Intravascular aggregation and pulmonary sequestration of platelets during IgE-induced systemic anaphy-laxis in the rabbit:abrogation of lethal anaphylactic shock by platelet depletion. J Immunol 119(6):2185–2193PubMedGoogle Scholar
  48. 48.
    Pretolani M, Page CP, Lefort J, Lagente V, Vargaftig BB (1986) Pharmacological modulation of the respiratory and haematological changes accompanying active anaphylaxis in the guinea-pig. Eur J Pharmacol 125(3):403–409PubMedCrossRefGoogle Scholar
  49. 49.
    Arnoux B, Denjean A, Page CP, Nolibe D, Morley J, Benveniste J (1988) Accumulation of platelets and eosinophils in baboon lung after paf-acether challenge:inhibition by ketotifen. Am Rev Respir Dis 137(4):855–860PubMedGoogle Scholar
  50. 50.
    Page CP, Tomiak RH, Sanjar S, Morley J (1985) Suppression of Paf-acether responses:an anti-inflammatory effect of anti-asthma drugs. Agents Actions 16(1–2):33–35PubMedCrossRefGoogle Scholar
  51. 51.
    Lellouch-Tubiana A, Lefort J, Pirotzky E, Vargaftig BB, Pfister A (1985) Ultrastructural evidence for extravascular platelet recruitment in the lung upon intravenous injection of platelet-activating factor (PAF-acether) to guinea-pigs. Brit J Exp Pathol 66(3):345–355Google Scholar
  52. 52.
    Lellouch-Tubiana A, Lefort J, Simon MT, Pfister A, Vargaftig BB (1988) Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists. Am Rev Respir Dis 137(4):948–954Google Scholar
  53. 53.
    Coyle AJ, Spina D, Page CP (1990) PAF-induced bronchial hyperresponsiveness in the rabbit:contribution of platelets and airway smooth muscle. Brit J Pharmacol 101(1):31–38Google Scholar
  54. 54.
    Coyle AJ, Page CP, Atkinson L, Flanagan R, Metzger WJ (1990) The requirement for platelets in allergen-induced late asthmatic airway obstruction. Eosinophil infiltration and heightened airway responsiveness in allergic rabbits. Am Rev Respir Dis 142(3):587–593Google Scholar
  55. 55.
    Pitchford SC, Yano H, Lever R, Riffo-Vasquez Y, Ciferri S, Rose MJ, Giannini S, Momi S, Spina D, O'Connor B, Gresele P, Page CP (2003) Platelets are essential for leukocyte recruitment in allergic inflammation. J Allergy Clin Immunol 112(1):109–118PubMedCrossRefGoogle Scholar
  56. 56.
    Pitchford SC, Riffo-Vasquez Y, Sousa A, Momi S, Gresele P, Spina D, Page CP (2004) Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation. Blood 103(2):639–647PubMedCrossRefGoogle Scholar
  57. 57.
    Lukacs NW, John A, Berlin A, Bullard DC, Knibbs R, Stoolman LM (2002) E- and P-selectins are essential for the development of cockroach allergen-induced airway responses. J Immunol 169(4):2120–2125PubMedGoogle Scholar
  58. 58.
    Huo Y, Schober A, Forlow SB, Smith DF, Hyman MC, Jung S, Littman DR, Weber C, Ley K (2003) Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipo-protein E. Nat Med 9(1):61–67PubMedCrossRefGoogle Scholar
  59. 59.
    Jawien J, Lomnicka M, Korbut R, Chlopicki S (2005) The involvement of adhesion molecules and lipid mediators in the adhesion of human platelets to eosinophils. J Physiol Pharmacol 56(4):637–648PubMedGoogle Scholar
  60. 60.
    Watanabe O, Natori K, Tamari M, Shiomoto Y, Kubo S, Nakamura Y (1999) Significantly elevated expression of PF4 (platelet factor 4) and eotaxin in the NOA mouse, a model for atopic dermatitis. J Hum Genet 44(3):173–176PubMedCrossRefGoogle Scholar
  61. 61.
    Tamagawa-Mineoka R, Katoh N, Ueda E, Takenaka H, Kita M, Kishimoto S (2007) The role of platelets in leukocyte recruitment in chronic contact hypersensitivity induced by repeated elicitation. Am J Pathol 170(6):2019–2029PubMedCrossRefGoogle Scholar
  62. 62.
    Foster AP, Lees P, Cunningham FM (1995) Platelet activating factor mimics antigen-induced cutaneous inflammatory responses in sweet itch horses. Vet Immunol Immunopathol 44(2):115–128PubMedCrossRefGoogle Scholar
  63. 63.
    Furukawa H, Nakamura K, Zheng X, Tojo M, Oyama N, Akiba H, Nishibu A, Kaneko F, Tsunemi Y, Saeki H, Tamaki K (2004) Enhanced TARC production by dust-mite allergens and its modulation by immunosuppressive drugs in PBMCs from patients with atopic dermatitis. J Dermatol Sci 35(1):35–42PubMedCrossRefGoogle Scholar
  64. 64.
    Vestergaard C, Deleuran M, Gesser B, Larsen CG (2004) Thymus- and activation-regulated chemokine (TARC/CCL17) induces a Th2-dominated inflammatory reaction on intradermal injection in mice. Exp Dermatol 13(4):265–271PubMedCrossRefGoogle Scholar
  65. 65.
    Gear AR, Suttitanamongkol S, Viisoreanu D, Polanowska-Grabowska RK, Raha S, Camerini D (2001) Adenosine diphosphate strongly potentiates the ability of the chemokines MDC, TARC, and SDF-1 to stimulate platelet function. Blood 97(4):937–945PubMedCrossRefGoogle Scholar
  66. 66.
    Page CP and Pitchford SC (2005) Platelets. In:Encyclopedia of Respiratory Medicine. Eds:Laurent GJ and Shapiro SD. Elsevier, Cambridge, pp 347–351Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Kristin N. Kornerup
    • 1
  • Clive P. Page
    • 1
  1. 1.Sackler Institute of Pulmonary Pharmacology and TherapeuticsSchool of Biomedical and Health Sciences, King's College LondonLondonUK

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