Function of Dendritic Cell Subsets in Allergic Disease

  • Bart N. Lambrecht
  • Hamida Hammad
Part of the Allergy Frontiers book series (ALLERGY, volume 2)


There are many subsets of dendritic cells (DCs) that are distributed in various anatomical compartments throughout the lining mucosae, skin, and internal organs. In homeostatic conditions, a fine-tuned balance exists between plasmacytoid and myeloid dendritic cells necessary for maintaining tolerance to allergen and avoiding overt inflammation. These subsets of DCs also play important roles in the establishment of allergic inflammation seen in asthma, rhinitis, and atopic dermatitis. Based on these new insights on DC biology, several approaches that interfere with DC function show potential as new intervention strategies for these ever-increasing diseases.


Dendritic Cell Atopic Dermatitis Allergic Rhinitis Allergic Disease Allergy Clin Immunol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Steinman, R.M. and Z.A. Cohn. 1973. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 137:1142–1162.PubMedCrossRefGoogle Scholar
  2. 2.
    Lambrecht, B.N. and H. Hammad. 2003. Taking our breath away: dendritic cells in the patho-genesis of asthma. Nat Rev Immunol 3:994–1003.PubMedCrossRefGoogle Scholar
  3. 3.
    Shortman, K. and Y.J. Liu. 2002. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2:151–161.PubMedCrossRefGoogle Scholar
  4. 4.
    Merad, M., M.G. Manz, H. Karsunky, A. Wagers, W. Peters, I. Charo, I.L. Weissman, J.G. Cyster, and E.G. Engleman. 2002. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol 3:1135–1141.PubMedCrossRefGoogle Scholar
  5. 5.
    Geissmann, F., S. Jung, and D.R. Littman. 2003. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19:71–82.PubMedCrossRefGoogle Scholar
  6. 6.
    Bonasio, R. and U.H. von Andrian. 2006. Generation, migration and function of circulating dendritic cells. Curr Opin Immunol 18:503–511.PubMedCrossRefGoogle Scholar
  7. 7.
    del Hoyo, G.M., P. Martin, H.H. Vargas, S. Ruiz, C.F. Arias, and C. Ardavin. 2002. Characterization of a common precursor population for dendritic cells. Nature 415:1043–1047.PubMedCrossRefGoogle Scholar
  8. 8.
    Naik, S.H., D. Metcalf, A. van Nieuwenhuijze, I. Wicks, L. Wu, M. O'Keeffe, and K. Shortman. 2006. Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol 7:663–671.PubMedCrossRefGoogle Scholar
  9. 9.
    Figdor, C.G., Y. van Kooyk, and G.J. Adema. 2002. C-type lectin receptors on dendritic cells and Langerhans cells. Nat Rev Immunol 2:77–84.PubMedCrossRefGoogle Scholar
  10. 10.
    Mahnke, K., M. Guo, S. Lee, H. Sepulveda, S.L. Swain, M. Nussenzweig, and R.M. Steinman. 2000. The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. J Cell Biol 151:673–684.PubMedCrossRefGoogle Scholar
  11. 11.
    Currie, A.J., G.A. Stewart, and A.S. McWilliam. 2000. Alveolar macrophages bind and phagocytose allergen-containing pollen starch granules via C-type lectin and integrin receptors: implications for airway inflammatory disease. J Immunol 164:3878–3886.PubMedGoogle Scholar
  12. 12.
    Deslee Gt, G., H. Hammad, G. Angyalosi, I. Tillie-Leblond, A. Mantovani, A.B. Tonnel, and J. Pestel. 2002. Involvement of the mannose receptor in the uptake of der p 1, a major mite allergen, by human dendritic cells. J Allergy Clin Immunol 110:763–770.CrossRefGoogle Scholar
  13. 13.
    Novak, N., C. Tepel, S. Koch, K. Brix, T. Bieber, and S. Kraft. 2003. Evidence for a differential expression of the FcepsilonRIgamma chain in dendritic cells of atopic and nonatopic donors. J Clin Invest 111:1047–1056.PubMedGoogle Scholar
  14. 14.
    de Baey, A. and A. Lanzavecchia. 2000. The role of aquaporins in dendritic cell macropino-cytosis. J Exp Med 191:743–748.PubMedCrossRefGoogle Scholar
  15. 15.
    Inaba, K., M. Inaba, M. Naito, and R.M. Steinman. 1993. Dendritic cell progenitors phago-cytose particulates, including bacillus Calmette—Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J Exp Med 178:479–488.PubMedCrossRefGoogle Scholar
  16. 16.
    Ochando, J.C., C. Homma, Y. Yang, A. Hidalgo, A. Garin, F. Tacke, V. Angeli, Y. Li, P. Boros, Y. Ding, R. Jessberger, G. Trinchieri, S.A. Lira, G.J. Randolph, and J.S. Bromberg. 2006. Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat Immunol 7:652–662.PubMedCrossRefGoogle Scholar
  17. 17.
    Yang, D., O. Chertov, S.N. Bykovskaia, Q. Chen, M.J. Buffo, J. Shogan, M. Anderson, J.M. Schroder, J.M. Wang, O.M. Howard, and J.J. Oppenheim. 1999. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286:25–528.CrossRefGoogle Scholar
  18. 18.
    Biragyn, A., P.A. Ruffini, C.A. Leifer, E. Klyushnenkova, A. Shakhov, O. Chertov, A.K. Shirakawa, J.M. Farber, D.M. Segal, J.J. Oppenheim, and L.W. Kwak. 2002. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 298:1025–1029.PubMedCrossRefGoogle Scholar
  19. 19.
    Cook, D.N., D.M. Prosser, R. Forster, J. Zhang, N.A. Kuklin, S.J. Abbondanzo, X.D. Niu, S.C. Chen, D.J. Manfra, M.T. Wiekowski, L.M. Sullivan, S.R. Smith, H.B. Greenberg, S.K. Narula, M. Lipp, and S.A. Lira. 2000. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 12:495–503.PubMedCrossRefGoogle Scholar
  20. 20.
    Vermi, W., E. Riboldi, V. Wittamer, F. Gentili, W. Luini, S. Marrelli, A. Vecchi, J.D. Franssen, D. Communi, L. Massardi, M. Sironi, A. Mantovani, M. Parmentier, F. Facchetti, and S. Sozzani. 2005. Role of ChemR23 in directing the migration of myeloid and plasmacy-toid dendritic cells to lymphoid organs and inflamed skin. J Exp Med 201:509–515.PubMedCrossRefGoogle Scholar
  21. 21.
    Banchereau, J. and R.M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392:245–252.PubMedCrossRefGoogle Scholar
  22. 22.
    Vermaelen, K.Y., I. Carro-Muino, B.N. Lambrecht, and R.A. Pauwels. 2001. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J Exp Med 193:51–60.PubMedCrossRefGoogle Scholar
  23. 23.
    Lotze, M.T. and K.J. Tracey. 2005. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 5:331–342.PubMedCrossRefGoogle Scholar
  24. 24.
    Lambrecht, B.N. 2006. An unexpected role for the anaphylatoxin receptor C5aR in allergic sensitization. J Clin Invest 116:628–632.PubMedCrossRefGoogle Scholar
  25. 25.
    Lambrecht, B.N. 2001. Immunologists getting nervous: neuropeptides, dendritic cells and T cell activation. Respir Res 2:133–138.PubMedCrossRefGoogle Scholar
  26. 26.
    Lambrecht, B.N. and H. Hammad. 2003. The other cells in asthma: dendritic cell and epithelial cell crosstalk. Curr Opin Pulm Med 9:34–41.PubMedCrossRefGoogle Scholar
  27. 27.
    Sallusto, F., P. Schaerli, P. Loetscher, C. Schaniel, D. Lenig, C.R. Mackay, S. Qin, and A. Lanzavecchia. 1998. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur J Immunol 28:2760–2769.PubMedCrossRefGoogle Scholar
  28. 28.
    Idzko, M., H. Hammad, M. van Nimwegen, M. Kool, T. Muller, T. Soullie, M.A. Willart, D. Hijdra, H.C. Hoogsteden, and B.N. Lambrecht. 2006. Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. J Clin Invest 116:2935–2944.PubMedCrossRefGoogle Scholar
  29. 29.
    Hammad, H., H.J. de Heer, T. Souillie, H.C. Hoogsteden, F. Trottein, and B.N. Lambrecht. 2003. Prostaglandin D2 modifies airway dendritic cell migration and function in steady state conditions by selective activation of the DP-receptor. J Immunol 171:3936–3940.PubMedGoogle Scholar
  30. 30.
    Robbiani, F., R.A. Finch, D. Jager, W.A. Muller, A.C. Sartorelli, and G.J. Randolph. 2000. The leukotriene C4 transporter MRP1 regulates CCL19 (MIP-3, ELC)-dependent mobilization of dendritic cells to lymph nodes. Cell 103:757–768.PubMedCrossRefGoogle Scholar
  31. 31.
    Jakubzick, C., F. Tacke, J. Llodra, N. van Rooijen, and G.J. Randolph. 2006. Modulation of dendritic cell trafficking to and from the airways. J Immunol 176:3578–3584.PubMedGoogle Scholar
  32. 32.
    Qu, C., E.W. Edwards, F. Tacke, V. Angeli, J. Llodra, G. Sanchez-Schmitz, A. Garin, N.S. Haque, W. Peters, N. van Rooijen, C. Sanchez-Torres, J. Bromberg, I.F. Charo, S. Jung, S.A. Lira, and G.J. Randolph. 2004. Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J Exp Med 200:1231–1241.PubMedCrossRefGoogle Scholar
  33. 33.
    Stoll, S., J. Delon, T.M. Brotz, and R.N. Germain. 2002. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296:1873–1876.PubMedCrossRefGoogle Scholar
  34. 34.
    Castellino, F., A.Y. Huang, G. Altan-Bonnet, S. Stoll, C. Scheinecker, and R.N. Germain. 2006. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell—dendritic cell interaction. Nature 440:890–895.PubMedCrossRefGoogle Scholar
  35. 35.
    Qi, H., J.G. Egen, A.Y. Huang, and R.N. Germain. 2006. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312:1672–1676.PubMedCrossRefGoogle Scholar
  36. 36.
    Lambrecht, B.N., R.A. Pauwels, and B. Fazekas De St Groth. 2000. Induction of rapid T cell activation, division, and recirculation by intratracheal injection of dendritic cells in a TCR transgenic model. J Immunol 164:2937–2946.PubMedGoogle Scholar
  37. 37.
    Shiow, L.R., D.B. Rosen, N. Brdickova, Y. Xu, J. An, L.L. Lanier, J.G. Cyster, and M. Matloubian. 2006. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440:540–544.PubMedCrossRefGoogle Scholar
  38. 38.
    von Garnier, C., L. Filgueira, M. Wikstrom, M. Smith, J.A. Thomas, D.H. Strickland, P.G. Holt, and P.A. Stumbles. 2005. Anatomical location determines the distribution and function of dendritic cells and other APCs in the respiratory tract. J Immunol 175:1609–1618.Google Scholar
  39. 39.
    de Heer, H.J., H. Hammad, M. Kool, and B.N. Lambrecht. 2005. Dendritic cell subsets and immune regulation in the lung. Semin Immunol 17:295–303.PubMedCrossRefGoogle Scholar
  40. 40.
    Sung, S.S., S.M. Fu, C.E. Rose, Jr., F. Gaskin, S.T. Ju, and S.R. Beaty. 2006. A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. J Immunol 176:2161–2172.PubMedGoogle Scholar
  41. 41.
    Wikstrom, M.E. and P.A. Stumbles. 2007. Mouse respiratory tract dendritic cell subsets and the immunological fate of inhaled antigens. Immunol Cell Biol 85:182–188.PubMedGoogle Scholar
  42. 42.
    Demedts, I.K., K.R. Bracke, T. Maes, G.F. Joos, and G.G. Brusselle. 2006. Different roles for human lung dendritic cell subsets in pulmonary immune defense mechanisms. Am J Respir Cell Mol Biol 35:387–393.PubMedCrossRefGoogle Scholar
  43. 43.
    Masten, B.J., G.K. Olson, C.A. Tarleton, C. Rund, M. Schuyler, R. Mehran, T. Archibeque, and M.F. Lipscomb. 2006. Characterization of myeloid and plasmacytoid dendritic cells in human lung. J Immunol 177:7784–7793.PubMedGoogle Scholar
  44. 44.
    del Rio, M.-L., J.-I. Rodriguez-Barbosa, E. Kremmer, and R. Forster. 2007. CD103− and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells. J Immunol 178:6861–6866.PubMedGoogle Scholar
  45. 45.
    van Rijt, L.S., S. Jung, A. Kleinjan, N. Vos, M. Willart, C. Duez, H.C. Hoogsteden, and B.N. Lambrecht. 2005. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med 201:981–991.PubMedCrossRefGoogle Scholar
  46. 46.
    Cleret, A., A. Quesnel-Hellmann, A. Vallon-Eberhard, B. Verrier, S. Jung, D. Vidal, J. Mathieu, and J.N. Tournier. 2007. Lung dendritic cells rapidly mediate anthrax spore entry through the pulmonary route. J Immunol 178:7994–8001.PubMedGoogle Scholar
  47. 47.
    De Heer, H.J., H. Hammad, T. Soullie, D. Hijdra, N. Vos, M.A. Willart, H.C. Hoogsteden, and B.N. Lambrecht. 2004. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med 200:89–98.PubMedCrossRefGoogle Scholar
  48. 48.
    Jahnsen, F.L., D.H. Strickland, J.A. Thomas, I.T. Tobagus, S. Napoli, G.R. Zosky, D.J. Turner, P.D. Sly, P.A. Stumbles, and P.G. Holt. 2006. Accelerated antigen sampling and transport by airway mucosal dendritic cells following inhalation of a bacterial stimulus. J Immunol 177:5861–5867.PubMedGoogle Scholar
  49. 49.
    Xanthou, G., T. Alissafi, M. Semitekolou, D.C. Simoes, E. Economidou, M. Gaga, B.N. Lambrecht, C.M. Lloyd, and V. Panoutsakopoulou. 2007. Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets. Nat Med 13:570–578.PubMedCrossRefGoogle Scholar
  50. 50.
    Hintzen, G., L. Ohl, M.L. del Rio, J.I. Rodriguez-Barbosa, O. Pabst, J.R. Kocks, J. Krege, S. Hardtke, and R. Forster. 2006. Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node. J Immunol 177:7346–7354.PubMedGoogle Scholar
  51. 51.
    Van Hove, C.L., T. Maes, G.F. Joos, and K.G. Tournoy. 2007. Prolonged inhaled allergen exposure can induce persistent tolerance. Am J Respir Cell Mol Biol 36:573–584.PubMedCrossRefGoogle Scholar
  52. 52.
    Akbari, O., G.J. Freeman, E.H. Meyer, E.A. Greenfield, T.T. Chang, A.H. Sharpe, G. Berry, R.H. DeKruyff, and D.T. Umetsu. 2002. Antigen-specific regulatory T cells develop via the ICOS—ICOS—ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med 8:1024–1032.PubMedCrossRefGoogle Scholar
  53. 53.
    Ostroukhova, M., C. Seguin-Devaux, T.B. Oriss, B. Dixon-McCarthy, L. Yang, B.T. Ameredes, T.E. Corcoran, and A. Ray. 2004. Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3. J Clin Invest 114:28–38.PubMedGoogle Scholar
  54. 54.
    Piggott, D.A., S.C. Eisenbarth, L. Xu, S.L. Constant, J.W. Huleatt, C.A. Herrick, and K. Bottomly. 2005. MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J Clin Invest 115:459–467.PubMedGoogle Scholar
  55. 55.
    Hashimoto, K., J.R. Sheller, J.D. Morrow, R.D. Collins, K. Goleniewska, J. O'Neal, W. Zhou, S. Ji, D.B. Mitchell, B.S. Graham, and R.S. Peebles, Jr. 2005. Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms. J Immunol 174:525–532.PubMedGoogle Scholar
  56. 56.
    Hammad, H., M. Kool, T. Soullie, S. Narumiya, F. Trottein, H.C. Hoogsteden, and B.N. Lambrecht. 2007. Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. J Exp Med 204:357–367.PubMedCrossRefGoogle Scholar
  57. 57.
    Zhou, W., K. Hashimoto, K. Goleniewska, J.F. O'Neal, S. Ji, T.S. Blackwell, G.A. Fitzgerald, K.M. Egan, M.W. Geraci, and R.S. Peebles, Jr. 2007. Prostaglandin I2 analogs inhibit proin-flammatory cytokine production and T cell stimulatory function of dendritic cells. J Immunol 178:702–710.PubMedGoogle Scholar
  58. 58.
    Idzko, M., H. Hammad, M. van Nimwegen, M. Kool, N. Vos, H.C. Hoogsteden, and B.N. Lambrecht. 2007. Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function. J Clin Invest 117:464–472.PubMedCrossRefGoogle Scholar
  59. 59.
    Oriss, T.B., M. Ostroukhova, C. Seguin-Devaux, B. Dixon-McCarthy, D.B. Stolz, S.C. Watkins, B. Pillemer, P. Ray, and A. Ray. 2005. Dynamics of dendritic cell phenotype and interactions with CD4+ T cells in airway inflammation and tolerance. J Immunol 174:854–863.PubMedGoogle Scholar
  60. 60.
    Kohl, J., R. Baelder, I.P. Lewkowich, M.K. Pandey, H. Hawlisch, L. Wang, J. Best, N.S. Herman, A.A. Sproles, J. Zwirner, J.A. Whitsett, C. Gerard, G. Sfyroera, J.D. Lambris, and M. Wills-Karp. 2006. A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. J Clin Invest 116:783–796.PubMedCrossRefGoogle Scholar
  61. 61.
    Ito, T., M. Yang, Y.H. Wang, R. Lande, J. Gregorio, O.A. Perng, X.F. Qin, Y.J. Liu, and M. Gilliet. 2007. Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand. J Exp Med 204:105–115.PubMedCrossRefGoogle Scholar
  62. 62.
    Grohmann, U., C. Volpi, F. Fallarino, S. Bozza, R. Bianchi, C. Vacca, C. Orabona, M.L. Belladonna, E. Ayroldi, G. Nocentini, L. Boon, F. Bistoni, M.C. Fioretti, L. Romani, C. Riccardi, and P. Puccetti. 2007. Reverse signaling through GITR ligand enables dexam-ethasone to activate IDO in allergy. Nat Med 13:579–586.PubMedCrossRefGoogle Scholar
  63. 63.
    Idzko, M., H. Hammad, M. van Nimwegen, M. Kool, M.A. Willart, F. Muskens, H.C. Hoogsteden, W. Luttmann, D. Ferrari, F. Di Virgilio, J.C. Virchow, Jr., and B.N. Lambrecht. 2007. Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med 13:913–919.PubMedCrossRefGoogle Scholar
  64. 64.
    Nolte, M.A., S. Leibundgut-Landmann, O. Joffre, and C.R. Sousa. 2007. Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo. J Exp Med 204:1487–1501.PubMedCrossRefGoogle Scholar
  65. 65.
    Noulin, N., V.F. Quesniaux, S. Schnyder-Candrian, B. Schnyder, I. Maillet, T. Robert, B.B. Vargaftig, B. Ryffel, and I. Couillin. 2005. Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin. J Immunol 175:6861–6869.PubMedGoogle Scholar
  66. 66.
    Zhou, B., M.R. Comeau, T. De Smedt, H.D. Liggitt, M.E. Dahl, D.B. Lewis, D. Gyarmati, T. Aye, D.J. Campbell, and S.F. Ziegler. 2005. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol 6:1047–1053.PubMedCrossRefGoogle Scholar
  67. 67.
    Lee, H.C. and S.F. Ziegler. 2007. Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB. Proc Natl Acad Sci USA 104:914–919.PubMedCrossRefGoogle Scholar
  68. 68.
    Ohta, K., N. Yamashita, M. Tajima, T. Miyasaka, J. Nakano, M. Nakajima, A. Ishii, T. Horiuchi, K. Mano, and T. Miyamoto. 1999. Diesel exhaust particulate induces airway hyperresponsiveness in a murine model: essential role of GM-CSF. J Allergy Clin Immunol 104:1024–1030.PubMedCrossRefGoogle Scholar
  69. 69.
    Bleck, B., D.B. Tse, I. Jaspers, M.A. Curotto de Lafaille, and J. Reibman. 2006. Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation. J Immunol 176:7431–7437.PubMedGoogle Scholar
  70. 70.
    Cates, E.C., R. Fattouh, J. Wattie, M.D. Inman, S. Goncharova, A.J. Coyle, J.C. Gutierrez-Ramos, and M. Jordana. 2004. Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism. J Immunol 173:6384–6392.PubMedGoogle Scholar
  71. 71.
    Holgate, S.T. 2007. The epithelium takes centre stage in asthma and atopic dermatitis. Trends Immunol 28:248–251.PubMedCrossRefGoogle Scholar
  72. 72.
    Moerloose, K.B., L.J. Robays, T. Maes, G.G. Brusselle, K.G. Tournoy, and G.F. Joos. 2006. Cigarette smoke exposure facilitates allergic sensitization in mice. Respir Res 7:49.PubMedCrossRefGoogle Scholar
  73. 73.
    Nouri-Shirazi, M., R. Tinajero, and E. Guinet. 2007. Nicotine alters the biological activities of developing mouse bone marrow-derived dendritic cells (DCs). Immunol Lett 109:155–164.PubMedCrossRefGoogle Scholar
  74. 74.
    Huh, J.C., D.H. Strickland, F.L. Jahnsen, D.J. Turner, J.A. Thomas, S. Napoli, I. Tobagus, P.A. Stumbles, P.D. Sly, and P.G. Holt. 2003. Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma. J Exp Med 198:19–30.PubMedCrossRefGoogle Scholar
  75. 75.
    Beaty, S.R., C.E. Rose, Jr. and S.S. Sung. 2007. Diverse and potent chemokine production by lung CD11bhi dendritic cells in homeostasis and in allergic lung inflammation. J Immunol 178:1882–1895.PubMedGoogle Scholar
  76. 76.
    Koya, T., T. Kodama, K. Takeda, N. Miyahara, E.S. Yang, C. Taube, A. Joetham, J.W. Park, A. Dakhama, and E.W. Gelfand. 2006. Importance of myeloid dendritic cells in persistent airway disease after repeated allergen exposure. Am J Respir Crit Care Med 173:42–55.PubMedCrossRefGoogle Scholar
  77. 77.
    Lewkowich, I.P., N.S. Herman, K.W. Schleifer, M.P. Dance, B.L. Chen, K.M. Dienger, A.A. Sproles, J.S. Shah, J. Kohl, Y. Belkaid, and M. Wills-Karp. 2005. CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J Exp Med 202:1549–1561.PubMedCrossRefGoogle Scholar
  78. 78.
    Van Rijt, L.S., N. Vos, M. Willart, A. Kleinjan, A.J. Coyle, H.C. Hoogsteden, and B.N. Lambrecht. 2004. Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma. J Allergy Clin Immunol 114:166–173.PubMedCrossRefGoogle Scholar
  79. 79.
    Schnyder-Candrian, S., D. Togbe, I. Couillin, I. Mercier, F. Brombacher, V. Quesniaux, F. Fossiez, B. Ryffel, and B. Schnyder. 2006. Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med 203:2715–2725.PubMedCrossRefGoogle Scholar
  80. 80.
    Robays, L.J., T. Maes, S. Lebecque, S.A. Lira, W.A. Kuziel, G.G. Brusselle, G.F. Joos, and K.V. Vermaelen. 2007. Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation. J Immunol 178:5305–5311.PubMedGoogle Scholar
  81. 81.
    Upham, J.W., J.A. Denburg, and P.M. O'Byrne. 2002. Rapid response of circulating myeloid dendritic cells to inhaled allergen in asthmatic subjects. Clin Exp Allergy 32:818–823.PubMedCrossRefGoogle Scholar
  82. 82.
    Bratke, K., M. Lommatzsch, P. Julius, M. Kuepper, H.D. Kleine, W. Luttmann, and J. Christian Virchow. 2007. Dendritic cell subsets in human bronchoalveolar lavage fluid after segmental allergen challenge. Thorax 62:168–175.PubMedCrossRefGoogle Scholar
  83. 83.
    Jahnsen, F.L., F. Lund-Johansen, J.F. Dunne, L. Farkas, R. Haye, and P. Brandtzaeg. 2000. Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy. J Immunol 165:4062–4068.PubMedGoogle Scholar
  84. 84.
    Farkas, L., E.O. Kvale, F.E. Johansen, F.L. Jahnsen, and F. Lund-Johansen. 2004. Plasmacytoid dendritic cells activate allergen-specific TH2 memory cells: modulation by CpG oligodeoxy-nucleotides. J Allergy Clin Immunol 114:436–443.PubMedCrossRefGoogle Scholar
  85. 85.
    Fokkens, W.J., T.M.A. Vroom, E. Rijnije, and P.G.H. Mulder. 1989. CD1+(T6)HLA-DR expressing cells, presumably Langerhans cells in nasal mucosa. Allergy 44:167.PubMedCrossRefGoogle Scholar
  86. 86.
    Godthelp, T., W.J. Fokkens, A. Kleinjan, A.F. Holm, P.G.H. Mulder, E.P. Prens, and E. Rijntjes. 1996. Antigen presenting cells in the nasal mucosa of patients with allergic rhinitis during allergen provocation. Clin Exp Allergy 26:677–688.PubMedCrossRefGoogle Scholar
  87. 87.
    Fokkens, W.J. 1999. Antigen-presenting cells in nasal allergy. Allergy 54:1130–1141.PubMedCrossRefGoogle Scholar
  88. 88.
    KleinJan, A., T. Godthelp, A.W. van Toornenenbergen, and W.J. Fokkens. 1997. Allergen binding to specific IgE in the nasal mucosa of allergic patients. J Allergy Clin Immunol 99:515–521.PubMedCrossRefGoogle Scholar
  89. 89.
    KleinJan, A., M. Willart, L.S. van Rijt, G.J. Braunstahl, K. Leman, S. Jung, H.C. Hoogsteden, and B.N. Lambrecht. 2006. An essential role for dendritic cells in human and experimental allergic rhinitis. J Allergy Clin Immunol 118:1117–1125.PubMedCrossRefGoogle Scholar
  90. 90.
    Holm, A.F., T. Godthelp, W.J. Fokkens, E.A. Severijnen, P.G. Mulder, T.M. Vroom, and E. Rijntjes. 1999. Long-term effects of corticosteroid nasal spray on nasal inflammatory cells in patients with perennial allergic rhinitis. Clin Exp Allergy 29:1356–1366.PubMedCrossRefGoogle Scholar
  91. 91.
    Stary, G., C. Bangert, G. Stingl, and T. Kopp. 2005. Dendritic cells in atopic dermatitis: expression of FcepsilonRI on two distinct inflammation-associated subsets. Int Arch Allergy Immunol 138:278–290.PubMedCrossRefGoogle Scholar
  92. 92.
    Wollenberg, A., S.P. Wen, and T. Bieber. 1995. Langerhans cell phenotyping: a new tool for differential diagnosis of inflammatory diseases. Lancet 346:1626–1627.PubMedCrossRefGoogle Scholar
  93. 93.
    Wollenberg, A., S. Kraft, D. Hanau, and T. Bieber. 1996. Immunomorphological and ultrastruc-tural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema. J Invest Dermatol 106:446–453.PubMedCrossRefGoogle Scholar
  94. 94.
    Novak, N., R. Valenta, B. Bohle, S. Laffer, J. Haberstok, S. Kraft, and T. Bieber. 2004. FcepsilonRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro. J Allergy Clin Immunol 113:949–957.PubMedCrossRefGoogle Scholar
  95. 95.
    Novak, N., J.P. Allam, T. Hagemann, C. Jenneck, S. Laffer, R. Valenta, J. Kochan, and T. Bieber. 2004. Characterization of FcepsilonRI-bearing CD123 blood dendritic cell antigen-2 plasmacytoid dendritic cells in atopic dermatitis. J Allergy Clin Immunol 114:364–370.PubMedCrossRefGoogle Scholar
  96. 96.
    Hammad, H. and B.N. Lambrecht. 2006. Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation. J Allergy Clin Immunol 118:331–336.PubMedCrossRefGoogle Scholar
  97. 97.
    Ettmayer, P., P. Mayer, F. Kalthoff, W. Neruda, N. Harrer, G. Hartmann, M.M. Epstein, V. Brinkmann, C. Heusser, and M. Woisetschlager. 2006. A novel low molecular weight inhibitor of dendritic cells and B cells blocks allergic inflammation. Am J Respir Crit Care Med 173:599–606.PubMedCrossRefGoogle Scholar
  98. 98.
    Matsubara, S., T. Koya, K. Takeda, A. Joetham, N. Miyahara, P. Pine, E.S. Masuda, C.H. Swasey, and E.W. Gelfand. 2006. Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation. Am J Respir Cell Mol Biol 34:426–433.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Bart N. Lambrecht
    • 1
  • Hamida Hammad
    • 2
  1. 1.Department of Respiratory Diseases, Laboratory of Mucosal ImmunologyMRB1, University Hospital GhentGhentBelgium
  2. 2.Department of Raspiratory DiseasesUniversity Hospital GhentBelgium

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