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Dendritic Cells, Macrophages and Monocytes in Allergic Disease

  • Alexander Faith
  • Christopher Corrigan
  • Catherine M. Hawrylowicz
Part of the Allergy Frontiers book series (ALLERGY, volume 2)

Abstract

Antigen-presenting cells (APC) are present throughout mucosal surfaces of the skin, gut and respiratory tract. Dendritic cells (DC), the principal APC, receive and translate environmental signals, which promote maturation and migration to draining lymph nodes where DC can induce clonal expansion of antigen-specific naive T cells. The dendritic cell possesses the unique ability to induce differentiation of T cells, determine the nature of the T cell response and imprint the ability of memory T cells to home to peripheral tissues. The principal mucosal DC subset, myeloid-DC, has been implicated in the generation of Th2 cells, thus provoking inflammation in response to allergen challenge in susceptible individuals. Myeloid-DC, however, display functional plasticity and are also responsive to signals, which can promote a tolerogenic phenotype in DC. Tolerance induction at mucosal surfaces is proposed to depend on the induction and expansion by DC of T cells with regulatory function (Treg). Alveolar macrophages, which derive from a monocyte precursor, express an immunosuppressive phenotype in normal individuals, but display enhanced capacity to secrete inflammatory mediators and present antigen in patients with allergic inflammation, thus amplifying the inflammatory cascade. Antigen-presenting cells, therefore, represent a crucial target for novel methods of immunotherapeutic intervention in chronic allergen-driven inflammatory disease.

Keywords

Dendritic Cell Alveolar Macrophage Allergy Clin Immunol Drain Lymph Node Allergen Challenge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Iwasaki A (2007) Mucosal dendritic cells. Annu Rev Immunol 25:381–418PubMedCrossRefGoogle Scholar
  2. 2.
    Till SJ, Jacobson MR, O'Brien F, Durham SR, KleinJan A, Fokkens WJ, Juliusson S, Lowhagen O (2001) Recruitment of CD1a + Langerhans cells to the nasal mucosa in seasonal allergic rhinitis and effects of topical corticosteroid therapy. Allergy 56:126–131PubMedCrossRefGoogle Scholar
  3. 3.
    Geissmann F (2007) The origin of dendritic cells. Nat Immunol 8:558–566PubMedCrossRefGoogle Scholar
  4. 4.
    Wu L, Liu YJ (2007) Development of dendritic-cell lineage. Immunity 26:741–750PubMedCrossRefGoogle Scholar
  5. 5.
    Sung SS FS, Rose CE Jr, Gaskin F, Ju ST, Beaty SR (2006) A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. J Immunol 176:2161–2172PubMedGoogle Scholar
  6. 6.
    Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, Hall J, Sun CM, Belkaid Y, Powrie F (2007) A functionally specialized population of mucosal CD103 + DCs induces Foxp3 + regulatory T cells via a TGF-{beta} and retinoic acid dependent mechanism. J Exp Med 204:1757–1764PubMedCrossRefGoogle Scholar
  7. 7.
    van Haarst JM, Hoogsteden HC, de Wit HJ, Verhoeven GT, Havenith CE, Drexhage HA (1994) Dendritic cells and their precursors isolated from human bronchoalveolar lavage: immunocytologic and functional properties. Am J Respir Cell Mol Biol 11:344–350PubMedGoogle Scholar
  8. 8.
    Demedts IK, Brusselle GG, Vermaelen KY, Pauwels RA (2005) Identification and characterization of human pulmonary dendritic cells Am J Respir Cell Mol Biol 32:177–184PubMedCrossRefGoogle Scholar
  9. 9.
    Faith A, McDonald J, Peek E, Richards D, Caulfield J, Chevretton E, Roberts D, Lee T, Corrigan C, Hawrylowicz C 2005 Functional plasticity of human respiratory tract dendritic cells: GM-CSF enhances T(H)2 development. J Allergy Clin Immunol. 116:1136–1143PubMedCrossRefGoogle Scholar
  10. 10.
    KleinJan A, Willart M, van Rijt LS, Braunstahl GJ, Leman K, Jung S, Hoogsteden HC, Lambrecht BN (2006) An essential role for dendritic cells in human and experimental allergic rhinitis. J Allergy Clin Immunol 118:1117–1125PubMedCrossRefGoogle Scholar
  11. 11.
    Bell SJ, Rigby R, English N, Mann SD, Knight SC, Kamm MA, Stagg AJ (2001) Migration and maturation of human colonic dendritic cells J Immunol 166:4958–4967PubMedGoogle Scholar
  12. 12.
    Guttman-Yassky E, Lowes MA, Fuentes-Duculan J, Whynot J, Novitskaya I, Cardinale I, Haider A, Khatcherian A, Carucci JA, Bergman R, Krueger JG (2007) Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. J Allergy Clin Immunol 119:1210–1217PubMedCrossRefGoogle Scholar
  13. 13.
    Jahnsen FL, Gran E, Haye R, Brandtzaeg P (2004) Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypes. Am J Respir Cell Mol Biol 30:31–37PubMedCrossRefGoogle Scholar
  14. 14.
    Huh JC, Strickland DH, Jahnsen FL, Turner DJ, Thomas JA, Napoli S, Tobagus I, Stumbles PA, Sly PD, Holt PG (2003) Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma. J Exp Med 198:19–30PubMedCrossRefGoogle Scholar
  15. 15.
    Hochweller K, Anderton SM (2005) Kinetics of costimulatory molecule expression by T cells and dendritic cells during the induction of tolerance versus immunity in vivo. Eur J Immunol 35:1086–1096PubMedCrossRefGoogle Scholar
  16. 16.
    Steinman RM, Hemmi H (2006) Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 311:17–58PubMedCrossRefGoogle Scholar
  17. 17.
    Rissoan MC, Soumelis V, Kadowaki N, Grouard G, Briere F, de Waal Malefyt R, Liu YJ (1999) Reciprocal control of T helper cell and dendritic cell differentiation. Science 283: 1183–1186PubMedCrossRefGoogle Scholar
  18. 18.
    de Jong EC, Smits HH, Kapsenberg ML (2005) Dendritic cell-mediated T cell polarization. Springer Semin Immunopathol 2005 26:289–307CrossRefGoogle Scholar
  19. 19.
    Johansson-Lindbom B, Agace WW (2007) Generation of gut-homing T cells and their localization to the small intestinal mucosa. Immunol Rev 215:226–242PubMedCrossRefGoogle Scholar
  20. 20.
    Medoff BD, Thomas SY, Banerji A, Wain JC, Zhang H, Lilly CM, Ginns LC, Luster AD (2005) Pathogenic T-cell recruitment into the airway in human disease. Ann NY Acad Sci 1062:220–241PubMedCrossRefGoogle Scholar
  21. 21.
    Panina-Bordignon P, Papi A, Mariani M, Di Lucia P, Casoni G, Bellettato C, Buonsanti C, Miotto D, Mapp C, Villa A, Arrigoni G, Fabbri LM, Sinigaglia F (2001) The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest 107:1357–1364PubMedCrossRefGoogle Scholar
  22. 22.
    Pilette C, Francis JN, Till SJ, Durham S (2004) CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge. Eur Respir J 23:876–884PubMedCrossRefGoogle Scholar
  23. 23.
    Lambrecht BN, De Veerman M, Coyle AJ, Gutierrez-Ramos JC, Thielemans K, Pauwels R (2000) Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosi-nophilic airway inflammation. J Clin Invest 106:551–559PubMedCrossRefGoogle Scholar
  24. 24.
    Jahnsen FL, Moloney ED, Hogan T, Upham JW, Burke CM, Holt PG (2001) Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge. Thorax 56:823–826PubMedCrossRefGoogle Scholar
  25. 25.
    de Jong EC, Smits HH, Kapsenberg ML. (2005) Dendritic cell-mediated T cell polarization. Springer Semin Immunopathol 26:289–307PubMedCrossRefGoogle Scholar
  26. 26.
    Hallsworth MP, Soh CP, Lane SJ, Arm JP, Lee TH (1994) Selective enhancement of GM-CSF, TNF-alpha, IL-1 beta and IL-8 production by monocytes and macrophages of asthmatic subjects. Eur Respir J 7:1096–02PubMedGoogle Scholar
  27. 27.
    Soumelis V, Reche PA, Kanzler H, Yuan W, Edward G, Homey B, Gilliet M, Ho S, Antonenko S, Lauerma A, Smith K, Gorman D, Zurawski S, Abrams J, Menon S, McClanahan T, de Waal-Malefyt Rd R, Bazan F, Kastelein RA, Liu YJ (2002) Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 3:673–680PubMedGoogle Scholar
  28. 28.
    Ying S, O'Connor B, Ratoff J, Meng Q, Mallett K, Cousins D, Robinson D, Zhang G, Zhao J, Lee TH, Corrigan C (2005) Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 174:8183–8190PubMedGoogle Scholar
  29. 29.
    Bogiatzi SI, Fernandez I, Bichet JC, Marloie-Provost MA, Volpe E, Sastre X, Soumelis V (2007) Proinflammatory and Th2 cytokines synergize to induce thymic stromal lymphopoietin production by human skin keratinocytes. J Immunol 178:3373–3377PubMedGoogle Scholar
  30. 30.
    Faith A, Peek E, McDonald J, Urry Z, Richards DF, Tan C, Santis G, Hawrylowicz C (2007) Plasmacytoid dendritic cells from human lung cancer draining lymph nodes induce Tc1 responses. Am J Respir Cell Mol Biol 36:360–367PubMedCrossRefGoogle Scholar
  31. 31.
    Novak N, Allam JP, Hagemann T, Jenneck C, Laffer S, Valenta R, Kochan J, Bieber T (2004) Characterization of FcepsilonRI-bearing CD123 blood dendritic cell antigen-2 plasmacytoid dendritic cells in atopic dermatitis. J Allergy Clin Immunol 114:364–370PubMedCrossRefGoogle Scholar
  32. 32.
    de Heer HJ, Hammad H, Soullie T, Hijdra D, Vos N, Willart MA, Hoogsteden HC, Lambrecht BN (2004) Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med 200:89–98PubMedCrossRefGoogle Scholar
  33. 33.
    Creticos PS, Schroeder JT, Hamilton RG, Balcer-Whaley SL, Khattignavong AP, Lindblad R, Li H, Coffman R, Seyfert V, Eiden JJ, Broide D, Immune Tolerance Network Group (2006) Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med 355:1445–1455PubMedCrossRefGoogle Scholar
  34. 34.
    Gould HJ, Sutton BJ, Beavil AJ, Beavil RL, McCloskey N, Coker HA, Fear D, Smurthwaite L (2003) The biology of IGE and the basis of allergic disease. Annu Rev Immunol 21:579–628PubMedCrossRefGoogle Scholar
  35. 35.
    Prussin C, Griffith DT, Boesel KM, Lin H, Foster B, Casale TB (2003) Omalizumab treatment downregulates dendritic cell FcepsilonRI expression. J Allergy Clin Immunol 112:1147–1154PubMedCrossRefGoogle Scholar
  36. 36.
    Maurer D, Fiebiger S, Ebner C, Reininger B, Fischer GF, Wichlas S, Jouvin MH, Schmitt-Egenolf M, Kraft D, Kinet JP, Stingl G (1996) Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation. J Immunol 157: 607–616PubMedGoogle Scholar
  37. 37.
    von Bubnoff D, Hanau D, Wenzel J, Takikawa O, Hall B, Koch S, Bieber T (2003) Indoleamine 2,3-dioxygenase-expressing antigen-presenting cells and peripheral T-cell tolerance: another piece to the atopic puzzle? J Allergy Clin Immunol 112:854–640CrossRefGoogle Scholar
  38. 38.
    Hayashi T, Beck L, Rossetto C, Gong X, Takikawa O, Takabayashi K, Broide DH, Carson DA, Raz E (2004) Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest 114:270–279PubMedGoogle Scholar
  39. 39.
    von Bubnoff D, Fimmers R, Bogdanow M, Matz H, Koch S, Bieber T (2004) Asymptomatic atopy is associated with increased indoleamine 2,3-dioxygenase activity and interleukin-10 production during seasonal allergen exposure. Clin Exp Allergy 34:1056–1063CrossRefGoogle Scholar
  40. 40.
    Dombrowicz D, Lin S, Flamand V, Brini AT, Koller BH, Kinet JP (1998) Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses Immunity 8:517–529PubMedCrossRefGoogle Scholar
  41. 41.
    Umetsu DT, DeKruyff RH (2006) The regulation of allergy and asthma. Immunol Rev 212:238–255PubMedCrossRefGoogle Scholar
  42. 42.
    Hoyne GF, O'Hehir RE, Wraith DC, Thomas WR, Lamb JR (1993) Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice J Exp Med 1993 178:1783–1788CrossRefGoogle Scholar
  43. 43.
    Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT (2002) Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med 8:1024–1032PubMedCrossRefGoogle Scholar
  44. 44.
    de Heer HJ, Hammad H, Soullie T, Hijdra D, Vos N, Willart MA, Hoogsteden HC, Lambrecht BN (2004) Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med 200:89–98PubMedCrossRefGoogle Scholar
  45. 45.
    Akdis M, Verhagen J, Taylor A, Karamloo F, Karagiannidis C, Crameri R, Thunberg S, Deniz G, Valenta R, Fiebig H, Kegel C, Disch R, Schmidt-Weber CB, Blaser K, Akdis CA Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004 199:1567–1575PubMedCrossRefGoogle Scholar
  46. 46.
    Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF, Adikibi T, Pridgeon C, Dallman M, Loke TK, Robinson DS, Barrat FJ, O'Garra A, Lavender P, Lee TH, Corrigan C, Hawrylowicz CM (2006) Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest 116:146–155PubMedCrossRefGoogle Scholar
  47. 47.
    Hawrylowicz CM, O'Garra A (2005) Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma. Nat Rev Immunol 5:271–283PubMedCrossRefGoogle Scholar
  48. 48.
    Ling EM, Smith T, Nguyen XD, Pridgeon C, Dallman M, Arbery J, Carr VA, Robinson DS (2004) Relation of CD4 + CD25 + regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 363:608–615PubMedCrossRefGoogle Scholar
  49. 49.
    Jonuleit H, Schmitt E, Schuler G, Knop J, Enk AH (2002) Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 192:1213–1222CrossRefGoogle Scholar
  50. 50.
    Steinbrink K, Graulich E, Kubsch S, Knop J, Enk AH (2002) CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity. Blood 99:2468–2476PubMedCrossRefGoogle Scholar
  51. 51.
    Ito T, Yang M, Wang YH, Lande R, Gregorio J, Perng OA, Qin XF, Liu YJ, Gilliet M (2007) Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand. J Exp Med 204:105–115PubMedCrossRefGoogle Scholar
  52. 52.
    Gilliet M, Liu YJ (2002) Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells J Exp Med 196:695–704CrossRefGoogle Scholar
  53. 53.
    Strickland DH, Stumbles PA, Zosky GR, Subrata LS, Thomas JA, Turner DJ, Sly PD, Holt PG (2006) Reversal of airway hyperresponsiveness by induction of airway mucosal CD4 + CD25 + regulatory T cells. J Exp Med 203:2649–2660PubMedCrossRefGoogle Scholar
  54. 54.
    Hammad H, Kool M, Soullie T, Narumiya S, Trottein F, Hoogsteden HC, Lambrecht BN (2007) Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. J Exp Med 204:357–356PubMedCrossRefGoogle Scholar
  55. 55.
    Doganci A, Eigenbrod T, Krug N, De Sanctis GT, Hausding M, Erpenbeck VJ, Haddad el-B, Lehr HA, Schmitt E, Bopp T, Kallen KJ, Herz U, Schmitt S, Luft C, Hecht O, Hohlfeld JM, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Renz H, Neurath MF, Galle PR, Finotto S (2005) The IL-6R alpha chain controls lung CD4 + CD25 + Treg development and function during allergic airway inflammation in vivo. J Clin Invest 115:313–325PubMedGoogle Scholar
  56. 56.
    Gordon S, Taylor PR (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5:953–964PubMedCrossRefGoogle Scholar
  57. 57.
    Ziegler-Heitbrock HW, Fingerle G, Ströbel M, Schraut W, Stelter F, Schütt C, Passlick B, Pforte A (1993) The novel subset of CD14 +/CD16 + blood monocytes exhibits features of tissue macrophages Eur. J Immunol 23:2053–2058CrossRefGoogle Scholar
  58. 58.
    Lane SJ, Sousa AR, Lee TH (1994) The role of the macrophage in asthma. Allergy 49:201–209PubMedCrossRefGoogle Scholar
  59. 59.
    Takabayshi K, Corr M, Hayashi T, Redecke V, Beck L, Guiney D, Sheppard D, Raz E (2006) Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity 24:475–487PubMedCrossRefGoogle Scholar
  60. 60.
    Blumenthal RL, Campbell DE, Hwang P, DeKruyff RH, Frankel LR, Umetsu DT (2001) Human alveolar macrophages induce functional inactivation in antigen-specific CD4 T cells. J Allergy Clin Immunol 107:258–264PubMedCrossRefGoogle Scholar
  61. 61.
    Holt PG, Oliver J, Bilyk N, McMenamin C, McMenamin PG, Kraal G, Thepen T (1993) Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J Exp Med 177:397–407PubMedCrossRefGoogle Scholar
  62. 62.
    Tang C, Rolland JM, Li X, Ward C, Bish R, Walters EH (1998) Alveolar macrophages from atopic asthmatics, but not atopic nonasthmatics, enhance interleukin-5 production by CD4 + T cells. Am J Respir Crit Care Med 157:1120–1126PubMedGoogle Scholar
  63. 63.
    Gant V, Hamblin A (1991) Normal and sarcoid alveolar macrophages differ in their ability to present antigen and to cluster with autologous lymphocytes. Clin Exp Immunol 86: 494–499PubMedCrossRefGoogle Scholar
  64. 64.
    van Duin D, Medzhitov R, Shaw AC (2006) Triggering TLR signaling in vaccination. Trends Immunol 27:49–55PubMedCrossRefGoogle Scholar
  65. 65.
    Piggott DA, Eisenbarth SC, Xu L, Constant SL, Huleatt JW, Herrick CA, Bottomly K (2005) MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J Clin Invest 115:459–467PubMedGoogle Scholar
  66. 66.
    Noulin N, Quesniaux VF, Schnyder-Candrian S, Schnyder B, Maillet I, Robert T, Vargaftig BB, Ryffel B, Couillin I (2005) Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin. J Immunol 175:6861–6869PubMedGoogle Scholar
  67. 67.
    Sabroe I, Parker LC, Dockrell DH, Davies DE, Dower SK, Whyte MK (2007) Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 175:306–311PubMedCrossRefGoogle Scholar
  68. 68.
    Larche M, Till SJ, Haselden BM, North J, Barkans J, Corrigan CJ, Kay AB, Robinson DS (1998) Costimulation through CD86 is involved in airway antigen-presenting cell and T cell responses to allergen in atopic asthmatics. J Immunol 161:6375–6382PubMedGoogle Scholar
  69. 69.
    Bilyk N, Holt PG (1993) Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor. J Exp Med 177:1773–1777PubMedCrossRefGoogle Scholar
  70. 70.
    Paine R 3rd, Morris SB, Jin H, Wilcoxen SE, Phare SM, Moore BB, Coffey MJ, Toews GB (2001) Impaired functional activity of alveolar macrophages from GM-CSF-deficient mice. Am J Physiol Lung Cell Mol Physiol 281:L1210–1218PubMedGoogle Scholar
  71. 71.
    Faith A, Fernandez M, Caulfield J, Loke T-K, O'Connor B, Lee T, Corrigan C, Hawrylowicz C (2008) Role of cysteinyl leukotrienes in Th2 responses induced by GM-CSF. Allergy 63:168–175.PubMedGoogle Scholar
  72. 72.
    Peters-Golden M (2004) The alveolar macrophage: the forgotten cell in asthma. Am J Respir Cell Mol Biol 31:3–7PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Alexander Faith
    • 1
  • Christopher Corrigan
    • 1
  • Catherine M. Hawrylowicz
    • 1
  1. 1.Department of Asthma, Allergy and Respiratory Science, 5th Floor Thomas Guy HouseGuy's Hospital Campus, King's CollegeLondon

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