Expanded Role for EKLF/KLF1 Within the Hematopoietic Lineage

  • James J. Bieker


Erythroid Krüppel-like factor (EKLF) is a transcriptional activator that was originally identified in 1993 and has since provided a significant window into the carefully orchestrated process of erythroid gene expression, particularly as it plays a critical role in β-like hemoglobin switching. However, later observations have suggested other roles for this protein. This presentation discusses the lines of evidence that together open up a new hematopoietic horizon for EKLF function.


Erythroid Progenitor Hematopoietic Lineage Fetal Liver Cell Expanded Role Protein Kinase Casein Kinase 
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© Springer 2009

Authors and Affiliations

  • James J. Bieker
    • 1
  1. 1.Department of Developmental and Regenerative BiologyMount Sinai School of MedicineNew YorkUSA

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