Molecular Structures of Krüppel-like Factors
The Krüppel-like factor (KLF) family regulates several biological processes, such as self-renewal, proliferation, differentiation, development, and tissue-selectively restricted events of a cell at the transcriptional level. The KLF family has a highly conserved array of three C2H2-type zinc fingers with similarity to Drosophila Krüppel at the C-terminus, comprising a GC-rich DNA-binding domain, to mediate activation and/or repression of transcription. In contrast, the N-terminal regions of KLFs contain several distinct domains that are required for binding to chromatin-associated proteins, such as CtBP or Sin3A. We describe the structure—function aspects of KLFs, with a primary focus on the DNA-binding domains and the protein-binding domains.
KeywordsZinc Finger C2H2 Zinc Finger Histone Deacetylase HDAC1 Cys2His2 Zinc Finger Protein Ellenrieder Versus
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