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Krüppel-like Factors KLF6 and KLF6-SV1 in the Diagnosis and Treatment of Cancer

  • Analisa DiFeo
  • Goutham Narla
  • John A. Martignetti

Abstract

Beyond their initial identification in prostate cancer, the tumor suppressor KLF6 and its alternatively spliced oncogenic isoform KLF6-SV1 have now been associated with a number of human cancers. Expression patterns of each have been linked to tumor stage, disease recurrence, chemotherapy response and overall survival. Most recently, inhibition of KLF6-SV1 has been shown to increase survival in a pre-clinical model of ovarian cancer. This chapter reviews the basic biology of KLF6 and KLF6-SV1 as it relates to cancer, summarizes the published studies to date, and highlights the scientific rationale for therapeutically targeting KLF6 and KLF6-SV1 as a novel treatment paradigm.

Keywords

Prostate Cancer Ovarian Cancer PC3M Cell Hereditary Prostate Cancer Ovarian Cancer Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2009

Authors and Affiliations

  • Analisa DiFeo
    • 1
  • Goutham Narla
    • 1
  • John A. Martignetti
    • 1
    • 2
  1. 1.Department of Genetics and Genomic SciencesMount Sinai School of MedicineNew YorkUSA
  2. 2.Department of Oncological SciencesMount Sinai School of MedicineNew YorkUSA

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