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The Biology of Krüppel-like Factors pp 223–244Cite as

Krüppel-like Factors KLF6 and KLF6-SV1 in the Diagnosis and Treatment of Cancer

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Abstract

Beyond their initial identification in prostate cancer, the tumor suppressor KLF6 and its alternatively spliced oncogenic isoform KLF6-SV1 have now been associated with a number of human cancers. Expression patterns of each have been linked to tumor stage, disease recurrence, chemotherapy response and overall survival. Most recently, inhibition of KLF6-SV1 has been shown to increase survival in a pre-clinical model of ovarian cancer. This chapter reviews the basic biology of KLF6 and KLF6-SV1 as it relates to cancer, summarizes the published studies to date, and highlights the scientific rationale for therapeutically targeting KLF6 and KLF6-SV1 as a novel treatment paradigm.

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Authors and Affiliations

  1. Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA

    Analisa DiFeo, Goutham Narla & John A. Martignetti

  2. Department of Oncological Sciences, Mount Sinai School of Medicine, 1425 Madison Avenue, Room 14-70, New York, NY, 10029, USA

    John A. Martignetti

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  1. Analisa DiFeo
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  2. Goutham Narla
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  3. John A. Martignetti
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Correspondence to John A. Martignetti .

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Editors and Affiliations

  1. Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Ryozo Nagai

  2. Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Avenue Room 1170C, Box 1123, New York, NY, 10029, USA

    Scott L. Friedman

  3. Research Institute, International Medical Center of Japan, 162-8655, Shinjuku-ku, Tokyo, Japan

    Masato Kasuga

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DiFeo, A., Narla, G., Martignetti, J.A. (2009). Krüppel-like Factors KLF6 and KLF6-SV1 in the Diagnosis and Treatment of Cancer. In: Nagai, R., Friedman, S.L., Kasuga, M. (eds) The Biology of Krüppel-like Factors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-87775-2_17

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