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Krüppel-like Factors in Cancers

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The Biology of Krüppel-like Factors

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Abstract

Krüppel-like factors (KLFs) are zinc finger-containing transcription factors that play important roles in diverse physiological and pathophysiological processes. A major function of many KLFs is to regulate cell growth, proliferation, and differentiation. It is therefore not surprising that some of the KLFs are involved in tumorigenesis of various organs and tissues. This chapter reviews the pathobio-logical roles of KLFs in several cancers, including those of the gastrointestinal tract, breast, skin, and pancreas. Understanding the functions of KLFs in cancers may help gain insight into the pathogenesis of cancers and provide novel therapeutic approaches to their treatment.

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  1. Division of Digestive Diseases, Department of Medicine and Department of Hematology and Medical Oncology, Emory University School of Medicine, 210 Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA, 30322, USA

    Vincent W. Yang

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  1. Vincent W. Yang
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  1. Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Ryozo Nagai

  2. Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Avenue Room 1170C, Box 1123, New York, NY, 10029, USA

    Scott L. Friedman

  3. Research Institute, International Medical Center of Japan, 162-8655, Shinjuku-ku, Tokyo, Japan

    Masato Kasuga

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© 2009 Springer

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Yang, V.W. (2009). Krüppel-like Factors in Cancers. In: Nagai, R., Friedman, S.L., Kasuga, M. (eds) The Biology of Krüppel-like Factors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-87775-2_16

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