Krüppel-like Factors in Cancers

  • Vincent W. Yang


Krüppel-like factors (KLFs) are zinc finger-containing transcription factors that play important roles in diverse physiological and pathophysiological processes. A major function of many KLFs is to regulate cell growth, proliferation, and differentiation. It is therefore not surprising that some of the KLFs are involved in tumorigenesis of various organs and tissues. This chapter reviews the pathobio-logical roles of KLFs in several cancers, including those of the gastrointestinal tract, breast, skin, and pancreas. Understanding the functions of KLFs in cancers may help gain insight into the pathogenesis of cancers and provide novel therapeutic approaches to their treatment.


Familial Adenomatous Polyposis Adenomatous Polyposis Coli Human Colon Cancer Cell Line Physiol Gastrointest Liver Intestinal Tumorigenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer 2009

Authors and Affiliations

  • Vincent W. Yang
    • 1
  1. 1.Division of Digestive Diseases, Department of Medicine and Department of Hematology and Medical OncologyEmory University School of Medicine, 210 Whitehead Biomedical Research BuildingAtlantaUSA

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