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Krüppel-like Factors in the Vascular Endothelium

  • Guillermo García-Cardeña
  • Guadalupe Villarreal

Abstract

Although Krüppel-like factors (KLFs) have been the subject of extensive biological investigation, the role of this family of transcription factors in the biology and pathophysiology of the vascular endothelium is just becoming apparent. Most investigative efforts thus far have focused on KLF2, its contribution to the endothelial vasoprotective phenotype, and its possible impact on atherogenesis. This chapter reflects on the current state of the field and highlights evolving areas where KLFs are emerging as important regulators of endothelial function.

Keywords

Human Umbilical Vein Endothelial Cell Fluid Shear Stress KLF2 Expression Smooth Muscle Cell Migration Laminar Shear Stress 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2009

Authors and Affiliations

  • Guillermo García-Cardeña
    • 1
  • Guadalupe Villarreal
    • 1
    • 2
  1. 1.Laboratory for Systems Biology, Center for Excellence in Vascular Biology, Departments of PathologyHarvard Medical School and Brigham and Women's HospitalBostonUSA
  2. 2.Harvard-MIT Division of HealthSciences and TechnologyBostonUSA

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