Krüppel-like Factors in the Heart
Despite the development of numerous therapies, heart disease is a major source of morbidity, mortality, and economic burden to society worldwide. A better understanding of the molecular underpinnings that lead to heart failure are likely to facilitate the development of novel therapies. The Krüppel-like factor (KLF) family of zinc finger transcription factors play important roles in modulating cellular functions in a broad range of mammalian cell types, and accumulating evidence demonstrates important roles of these factors in cardiovascular biology. This chapter describes our current understanding of the role of the KLF gene family in cardiac biology and the potential for these factors to serve as therapeutic targets.
KeywordsConnective Tissue Growth Factor Cardiac Fibroblast Zinc Finger Transcription Factor Connective Tissue Growth Factor Expression Cardiac Fatty Acid
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