Abstract
Krüppel-like factor 15 (KLF15) has been implicated in energy metabolism in various tissues including muscle, heart, liver, and adipose tissue. The expression of KLF15 is induced by the synergistic action of CCAAT/enhancer-binding protein β (C/EBPβ) and C/EBPδ during the differentiation of preadipocytes into adipocytes. The time course of KLF15 expression during this process is similar to that for C/EBPα, and these two proteins appear to promote the differentiation program in a cooperative manner through induction of the peroxisome proliferator-activated receptor γ (PPARγ) gene and other adipocyte-specific genes. A combination of microarray-based chromatin immunoprecipitation and gene expression analyses identified six genes whose promoters bound KLF15 and whose expression was either increased or decreased by forced expression of KLF15 in 3T3-L1 adipocytes. The gene for adrenomedullin, a vasodilatory hormone implicated in the pathogenesis of obesity-induced hypertension and insulin resistance, was one of these genes whose expression appears to be regulated by KLF15. KLF15 may thus also control the function of mature adipocytes through regulation of such genes.
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References
Banerjee SS, Feinberg MW, Watanabe M et al (2003) The Kruppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis. J Biol Chem 278:2581–2584
Birsoy K, Chen Z, Friedman J (2008) Transcriptional regulation of adipogenesis by KLF4. Cell Metab 7:339–347
Delbarre F, Aucher C, Amor B et al (1974) Gout with adenine phosphoribosyltransferase deficiency. Biomedicine 21:82–85
Gray S, Feinberg MW, Hull S et al (2002) The Krüppel-like factor KLF15 regulates the insulinsensitive glucose transporter GLUT4. J Biol Chem 277:34322–34328
Gray S, Wang B, Orihuela Y et al (2007) Regulation of gluconeogenesis by Kruppel-like factor 15. Cell Metab 5:305–312
Halestrap AP, Price NT (1999) The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 343:281–299
Harmancey R, Senard JM, Rouet P et al (2007) Adrenomedullin inhibits adipogenesis under tran-scriptional control of insulin. Diabetes 56:553–563
Iankova I, Petersen RK, Annicotte JS et al (2006) Peroxisome proliferator-activated receptor gamma recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis. Mol Endocrinol 20:1494–1505
Kitamura K, Kangawa K, Kawamoto M et al (1993) Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 192:553–560
Li D, Yea S, Li S et al (2005) Kruppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. J Biol Chem 280:26941–26952
Mori T, Sakaue H, Iguchi H et al (2005) Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J Biol Chem 280:12867–12875
Myllyharju J (2008) Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets. Ann Med 40:402–417
Nagare T, Sakaue H, Takashima M et al (2009) The Kruppel-like factor KLF15 inhibits transcription of the adrenomedullin gene in adipocytes. Biochem Biophys Res Commun 379:98–103
Nambu T, Arai H, Komatsu Y et al (2005) Expression of the adrenomedullin gene in adipose tissue. Regul Pept 132:17–22
Oishi Y, Manabe I, Tobe K et al (2005) Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab 1:27–39
Paulmyer-Lacroix O, Desbriere R, Poggi M et al (2006) Expression of adrenomedullin in adipose tissue of lean and obese women. Eur J Endocrinol 155:177–185
Rangwala SM, Lazar MA (2000) Transcriptional control of adipogenesis. Annu Rev Nutr 20:535–559
Rosen ED, Spiegelman BM (2000) Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 16:145–171
Rosen ED, Spiegelman BM (2006) Adipocytes as regulators of energy balance and glucose home-ostasis. Nature 444:847–853
Sue N, Jack BH, Eaton SA et al (2008) Targeted disruption of the basic Kruppel-like factor gene (Klf3) reveals a role in adipogenesis. Mol Cell Biol 28:3967–3978
Teshigawara K, Ogawa W, Mori T et al (2005) Role of Kruppel-like factor 15 in PEPCK gene expression in the liver. Biochem Biophys Res Commun 327:920–926
Trayhurn P, Wang B, Wood IS (2008) Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? Br J Nutr 100:227–235
Uchida S, Tanaka Y, Ito H et al (2000) Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor. Mol Cell Biol 20:7319–7331
Yamamoto J, Ikeda Y, Iguchi H et al (2004) Kruppel-like factor KLF15 contributes to fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2. J Biol Chem 279:16954–16962
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Ogawa, W., Sakaue, H., Kasuga, M. (2009). Role of Krüppel-like Factor 15 in Adipocytes. In: Nagai, R., Friedman, S.L., Kasuga, M. (eds) The Biology of Krüppel-like Factors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-87775-2_12
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DOI: https://doi.org/10.1007/978-4-431-87775-2_12
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-87774-5
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