Krüppel-like Factors: Ingenious Three Fingers Directing Biology and Pathobiology

  • Ryozo Nagai
  • Ichiro Manabe
  • Toru Suzuki


Krüppel-like transcription factors (KLFs) participate in diverse physiological and pathological processes, such as cell growth, cell differentiation, tumorigenicity, metabolism, inflammation, and tissue remodeling in response to diverse external stress. The importance of KLFs has recently been appreciated as detailed mechanisms of their molecular functions have been rapidly unraveled. However, many questions remain to be addressed: for instance, (1) how is gene expression of KLFs regulated—in a developmental stage-specific manner or in terms of cell—cell interaction; (2) how do KLFs interplay with other cofactors amid the transcriptional network; and (3) need to explore the tertiary structure of KLFs. Given the importance of KLFs in disease biology, extensive investigations on KLFs are expected to lead to identification of therapeutic targets for many diseases.


Adenomatous Polyposis Coli Adipocyte Differentiation Phenotypic Modulation Histone Chaperone Acyclic Retinoid 


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© Springer 2009

Authors and Affiliations

  • Ryozo Nagai
    • Ichiro Manabe
      • Toru Suzuki

        There are no affiliations available

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