Biliary Carcinomas Induced in the Hamster

  • Yoshitsugu Tajima
  • Shizuo Yamanaka
  • Sumihiro Matsuzaki
  • Toshifumi Eto
  • Kazuya Okada
  • Hiroshi Shiku
  • Tsutomu Tomioka
  • Tsukasa Tsunoda
  • Takashi Kanematsu

Syrian hamsters were subjected to cholecystoduodenostomy with dissection of the common duct, and given N-nitrosobis(2-oxopropyl)amine (BOP). We then investigated the histomorphological characteristics of the adenomas and early carcinomas induced in the extrahepatic bile duct. The tumors that developed in the extrahepatic bile duct included 10 adenomas and 55 early carcinomas in 56 of the 156 hamsters killed. All the adenomas were polypoid in shape, whereas the early carcinomas, which were restricted to the mucosal layer of the bile duct, showed the following three different growth patterns: protruding in 41 (75%), 27 of which were polypoid and 14, papillary; superficial spreading in 9 (16%); and periductal glandular in 5 (9%). There were no depressed tumors. Carcinomas coexisting with or in adenoma were evident in 12 (22%) tumors, 11 of which were polypoid. Atypical papillary hyperplasia was seen within the tumor mass in 22 early carcinomas (40%) and was particularly prominent in papillary type tumors. These findings support the concept of an adenoma–carcinoma sequence in most polypoid tumors of the extrahepatic bile duct. Atypical papillary hyperplasia might also be premalignant, and these precursor lesions could reflect the growth patterns of tumors, at least in the early stage of tumorigenesis.


Bile Duct Extrahepatic Bile Duct Intrahepatic Bile Duct Common Duct Bile Duct Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2009

Authors and Affiliations

  • Yoshitsugu Tajima
    • Shizuo Yamanaka
      • 1
    • Sumihiro Matsuzaki
      • 2
    • Toshifumi Eto
      • 3
    • Kazuya Okada
      • 4
    • Hiroshi Shiku
      • 5
    • Tsutomu Tomioka
      • 6
    • Tsukasa Tsunoda
      • 7
    • Takashi Kanematsu
      1. 1.Department of SurgeryNarumidai Yamanaka ClinicNagasakiJapan
      2. 2.Department of SurgeryDialand Matsuzaki ClinicNagasakiJapan
      3. 3.Department of SurgeryEto HospitalIsahayaJapan
      4. 4.Department of SurgeryNagasaki Kouseikai HospitalNagasakiJapan
      5. 5.Department of Cancer Vaccine and Immuno-Gene TherapyMie University Graduate School of MedicineMieJapan
      6. 6.Department of SurgeryNagasaki Yurino HospitalNishisonogiJapan
      7. 7.Department of SurgeryDivision of Gastroenterological Surgery, Kawasaki Medical SchoolKurashikiJapan

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