Hamster Models of Biliary Carcinoma

  • Yoshitsugu Tajima
  • Tomoo Kitajima
  • Tsutomu Tomioka
  • Toshifumi Eto
  • Keiji Inoue
  • Tomohiro Fukahori
  • Makoto Sasaki
  • Tsukasa Tsunoda

Pancreaticobiliary maljunction (PBM) is a congenital anomaly characterized by a union of the pancreatic and biliary ducts, located outside the duodenal wall [1]. This anomalous condition has recently been recognized as a high risk factor for the development of biliary carcinomas later in life [2,3]. Two-way regurgitation occurs in this disorder, as the reflux of pancreatic juice up to the biliary tree and/or of bile up to pancreatic duct, because the sphincter muscle of Oddi does not act functionally in this anomalous union. Therefore, patients with PBM are prone to the development of various pathological conditions of the biliary tract and pancreas, including cholangitis, pancreatitis, biliary and pancreatic calculi, and eventually biliary carcinoma [2–6].

Different animal models have been developed to investigate the pathogenesis of PBM, using dogs [7–9], cats [10], goats [11], lambs [12], and rats [13], and the important documented findings of these studies may contribute to clinical practice. Since the pathogenesis of PBM-related diseases is broad, a variety of species and preparatory methods have been studied. In particular, the association between PBM and biliary carcinogenesis has been investigated extensively; however, few animal experiments have successfully induced biliary carcinoma.


Bile Duct Common Bile Duct Choledochal Cyst Gallbladder Carcinoma Extrahepatic Bile Duct 
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© Springer 2009

Authors and Affiliations

  • Yoshitsugu Tajima
    • Tomoo Kitajima
      • 1
    • Tsutomu Tomioka
      • 2
    • Toshifumi Eto
      • 3
    • Keiji Inoue
      • 1
    • Tomohiro Fukahori
      • 4
    • Makoto Sasaki
      • 5
    • Tsukasa Tsunoda
      • 6
    1. 1.Department of SurgeryNagasaki Municipal HospitalNagasakiJapan
    2. 2.Department of SurgeryNagasaki Yurino HospitalNishisonogiJapan
    3. 3.Department of SurgeryEto HospitalIsahayaJapan
    4. 4.Department of SurgeryAino Memorial HospitalUnzenJapan
    5. 5.Department of SurgeryNTT West Nagasaki HospitalNagasakiJapan
    6. 6.Department of SurgeryDivision of Gastroenterological Surgery, Kawasaki Medical SchoolKurashikiJapan

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