The Syrian Hamster as an Experimental Animal
The choice of an appropriate species and strain of laboratory animals is one of the scientist's major concerns. The Syrian hamster (Mesocricetus auratus) provides a unique tool for studying hepatobiliary and pancreatic carcinomas because the anatomical structure of its hepatobiliary and pancreatic duct system is similar to that of humans. Moreover, the tumors induced in the liver, biliary tract, and pancreas of hamsters with nitrosamines closely resemble those of humans. Biochemically, hamster bile is unsaturated under normal conditions and the bile acid composition is similar to human bile [1–4]. Pancreatic juice components in this species also resemble those of humans [5,6]. Therefore, the Syrian hamster may be an ideal animal model for investigating carcinogenic mechanisms in hepatobiliary and pancreatic tumors.
KeywordsBile Duct Common Bile Duct Pancreatic Duct Syrian Hamster Intrahepatic Bile Duct
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- 5.Helgeson AS, Pour P, Lawson T, Grandjean CJ. Exocrine pancreatic secretion in the Syrian golden hamster Mesocricetus auratus – I. Basic values. Comp Biochem Physiol 1980 66A:214–222.Google Scholar
- 7.Lebedev VS, Ivanova N V, Pavlova NK, Poltoraus AB. Molecular phylogeny of the Palearctic hamsters. In Proceedings of the International Conference Devoted to the 90th Anniversary of Prof. I. M. Gromov on Systematics, Phylogeny and Paleontology of Small Mammals, eds. Averianov A, Abramson N (2003). 114–118, Russian Academy of Science, St. Petersburg.Google Scholar
- 8.Musser GG, Carleton MD. Superfamily Muroidea. In Mammal Species of the World a Taxonomic and Geographic Reference, eds. Wilson DE, Reeder DM (2005). Johns Hopkins University Press, Baltimore, MD.Google Scholar
- 9.Moore MA, Thamavit W, Bannasch P. Tumours of the liver. In Pathology of Tumours in Laboratory Animals – Tumours of the Hamster, eds. Turusov VS, Mohr U, 2nd Ed., Vol. 3, pp. 79–108 (1996). International Agency for Research on Cancer, Lyon.Google Scholar
- 10.Turusov VS, Gorin B. Tumours of the gallbladder. In Pathology of Tumours in Laboratory Animals – Tumours of the Hamster, eds. Turusov VS, Mohr U, 2nd Ed., Vol. 3, pp. 109–125 (1996). International Agency for Research on Cancer, Lyon.Google Scholar
- 11.Tajima Y, Kitajima T, Tsuneoka N, Fukuda K, Kuroki T, Ikematsu Y, Tomioka T, Kanematsu T. Developmental process of biliary carcinoma arising in pancreaticobiliary maljunction – Experimental studies using a hamster model. In Pancreaticobiliary Maljunction, eds. Koyanagi Y, Aoki T, 1st Ed., pp. 219–227 (2002). Igaku Tosho Shuppan, Tokyo.Google Scholar
- 13.Pour PM, Tomioka T. Tumours of the pancreas. In Pathology of Tumours in Laboratory Animals – Tumours of the Hamster, eds. Turusov VS, Mohr U, 2nd Ed., Vol. 3, pp. 149–173 (1996). International Agency for Research on Cancer, Lyon.Google Scholar