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The Syrian Hamster as an Experimental Animal

  • Yoshitsugu Tajima

The choice of an appropriate species and strain of laboratory animals is one of the scientist's major concerns. The Syrian hamster (Mesocricetus auratus) provides a unique tool for studying hepatobiliary and pancreatic carcinomas because the anatomical structure of its hepatobiliary and pancreatic duct system is similar to that of humans. Moreover, the tumors induced in the liver, biliary tract, and pancreas of hamsters with nitrosamines closely resemble those of humans. Biochemically, hamster bile is unsaturated under normal conditions and the bile acid composition is similar to human bile [1–4]. Pancreatic juice components in this species also resemble those of humans [5,6]. Therefore, the Syrian hamster may be an ideal animal model for investigating carcinogenic mechanisms in hepatobiliary and pancreatic tumors.

Keywords

Bile Duct Common Bile Duct Pancreatic Duct Syrian Hamster Intrahepatic Bile Duct 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer 2009

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  • Yoshitsugu Tajima

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