Recent large-scale efforts in genome sequencing, expression profiling, and functional screening have produced an embarrassment of riches for life sciences researchers, and biological data can now be accessed in quantities that are orders of magnitude greater than were available even a few years ago. The growing need for interpretation of data sets, as well as the accelerating demand for their integration to a higher-level understanding of life, has set the stage for the advent of systems biology [1,2], in which biological processes and phenomena are approached as complex and dynamic systems. Systems biology is a natural extension of molecular biology and can be defined as “biology after identification of key gene(s).” We see systems biological research as a multistage process, beginning with the comprehensive identification and quantitative analysis of individual system components and their networked interactions, and leading to the ability to control existing systems toward the desired state and design new ones based on an understanding of structure and underlying dynamical principles (Fig. 1).
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Ueda, H.R. (2009). Systems Biology of Mammalian Circadian Clocks. In: Nakanishi, S., Kageyama, R., Watanabe, D. (eds) Systems Biology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-87704-2_6
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DOI: https://doi.org/10.1007/978-4-431-87704-2_6
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