Systems Biology of Mammalian Circadian Clocks

  • Hiroki R. Ueda

Recent large-scale efforts in genome sequencing, expression profiling, and functional screening have produced an embarrassment of riches for life sciences researchers, and biological data can now be accessed in quantities that are orders of magnitude greater than were available even a few years ago. The growing need for interpretation of data sets, as well as the accelerating demand for their integration to a higher-level understanding of life, has set the stage for the advent of systems biology [1,2], in which biological processes and phenomena are approached as complex and dynamic systems. Systems biology is a natural extension of molecular biology and can be defined as “biology after identification of key gene(s).” We see systems biological research as a multistage process, beginning with the comprehensive identification and quantitative analysis of individual system components and their networked interactions, and leading to the ability to control existing systems toward the desired state and design new ones based on an understanding of structure and underlying dynamical principles (Fig. 1).


System Biology Circadian Clock Clock Gene Circadian Oscillation Transcriptional Output 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2009

Authors and Affiliations

  • Hiroki R. Ueda
    • 1
  1. 1.Laboratory for Systems Biology and Functional Genomics Unit, Center for Developmental Biology, RIKENKobeJapan

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