Integrative Synaptic Mechanisms of the Neural Network
The cerebellum is a key neural substrate for motor coordination and motor learning [1,2]. The main neural circuitry of the cerebellum consists of two excitatory gluta-matergic pathways: the pons–mossy fiber–granule cell–parallel fibers and the inferior olive–climbing fibers . The inputs of mossy fibers and climbing fibers converge on Purkinje cells in the cerebellar cortex and deep cerebellar nuclei . Besides this main circuitry, Golgi cells receive excitatory parallel fiber input and suppress granule cell transmission via the inhibitory gamma-aminobutyric acid (GABA) transmitter. The cerebellar network has been well characterized by elec-trophysiology and morphology, and its input/output relationship is also relatively well quantitatively assessed by both electrophysiological and behavioral analysis. Our investigations have been concerned with the regulatory mechanisms of integra-tive synaptic transmission, which is responsible for motor learning and motor coordination in the cerebellar circuitry.
KeywordsPurkinje Cell Granule Cell Mossy Fiber Cerebellar Granule Cell Parallel Fiber
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