Advertisement

Dendritic Cells in Transplantation

Abstract

The transplantation of organs has expanded greatly over the past five decades. Transplantation represents the final therapeutic choice in patients with end-organ failure who can benefit from kidney, liver, heart, and lung transplantation. Hematopoietic cell transplantation and solid organ transplantation are definitive therapies for several otherwise fatal conditions. There have been tremendous developments regarding surgical procedures, applications of anesthetics, and technical understanding about preservation of organs during the past two or three decades, which have brought about a silent revolution regarding organ transplantation. From the surgical point of view, the transplantation operation is usually successful; however, the lifelong management of the different issues of posttransplantation patients is complex and difficult. The major problems following transplantation are the acute and chronic rejection of transplanted organs. Immunosuppressive agents are now widely used in most organ transplant recipients, leading to dramatically improved short-term (1–3 year) patient and graft survival rates, with 1-year graft survival approaching or exceeding 80% for many organ systems.

Keywords

Major Histocompatibility Complex Acute Rejection Chronic Rejection Tolerance Induction Liver Allograft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Recommended Readings

  1. Benseler V, McCaughan GW, Schlitt HJ, Bishop GA, Bowen DG, Bertolino P (2007) The liver: a special case in transplantation tolerance. Semin Liver Dis 27:194–213CrossRefPubMedGoogle Scholar
  2. Martinez OM, Rosen HR (2005) Dendritic cells, tolerance and therapy of organ allograft rejection. Contrib Nephrol 146:105–120Google Scholar
  3. McCurry KR, Colvin BL, Zahorchak AF, Thomson AW (2006) Regulatory dendritic cell therapy in organ transplantation. Transplant Int 19:525–538CrossRefGoogle Scholar
  4. Merad M, Collin M, Bromberg J (2007) Dendritic cell homeostasis and trafficking in transplantation. Trends Immunol 28:353–359CrossRefPubMedGoogle Scholar
  5. Morelli AE, Thomson AW (2003) Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction. Immunol Rev 196:125–146CrossRefPubMedGoogle Scholar
  6. Morelli AE, Thomson AW (2007) Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 7:610–621CrossRefPubMedGoogle Scholar
  7. Nouri-Shirazi M, Thomson AW (2006) Dendritic cells as promoters of transplant tolerance. Expert Opin Biol Ther 6:325–339CrossRefPubMedGoogle Scholar
  8. Raimondi G, Thomson AW (2005) Dendritic cells: tolerance and therapy of organ allograft rejection. Contrib Nephrol 146:105–120PubMedGoogle Scholar
  9. Young JW, Merad M, Hart DN (2007) Dendritic cells in transplantation and immune-based therapies. Biol Blood Marrow Transplant 13:23–32CrossRefPubMedGoogle Scholar

Copyright information

© Morikazu Onji and Sk. Md. Fazle Akbar 2008

Personalised recommendations