In 1868, a medical student, Paul Langerhans, discovered a population of dendritically shaped cells in the suprabasal region of the epidermis. These cells now bear his name. The reactivity of these cells to gold salt made him believe that the cells represented sensory nerve endings. However, today we know that Langerhans cells (LCs) are dendritic leukocytes, which perform a variety of activities. In particular, they function as professional antigen-presenting cells (APCs).
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