Skip to main content
SpringerLink
Log in
Book cover

Recent Advances in Thrombosis and Hemostasis 2008 pp 563–573Cite as

Current Clinical Status of Venous Thromboembolism in Japan

  • Chapter

  • 1334 Accesses

Abstract

Venous thromboembolism (VTE) is the third most common cardiovascular disease for which many clinical guidelines have been published in the Western world. In Japan, VTE has recently been recognized as a common disease and has received increased social as well as medical attention; however, the clinical diagnostic yield is still low. The most effective means of reducing unexpected death from VTE is to implement a comprehensive institutional policy of primary prophylaxis in patients at risk. Although it is difficult to prepare Japanese guidelines for prophylaxis of VTE based on reliable evidence, epidemiological information is available in the general surgical, orthopedic, and gynecological areas of practice. Finally, the first Japanese guidelines for prophylaxis of VTE were published in the spring of 2004. In addition, the diagnostic and management strategies have changed along with improvement in modalities and coverage by thrombolytic agents. The next goal is to gather evidence that provides the foundation for guidelines on treatment and prophylaxis. Large-scale research studies similar to those performed in the West should be conducted to elucidate the pathological mechanisms of VTE and improve its management.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Task Force on Pulmonary Embolism, European Society of Cardiology (2000) Guidelines on diagnosis and management of acute pulmonary embolism. Eur Heart J 21:1301–1336

    Article  Google Scholar 

  2. British Thoracic Society Standards of Care Committee Pulmonary Embolism Guideline Development Group (2003) British Thoracic Society guidelines for the management of suspected acute pulmonary embolism. Thorax 58:470–483

    Article  Google Scholar 

  3. Geerts WH, Pineo GF, Heit JA, et al (2004) Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126:338S–400S

    Article  PubMed  CAS  Google Scholar 

  4. Nicolaides AN, Breddin HK, Fareed J, et al (2001) Prevention of venous thromboembolism: international consensus statement-guidelines compiled in accordance with the scientific evidence. Int Angiol 20:1–37

    Article  PubMed  CAS  Google Scholar 

  5. Japanese Society of Pulmonary Embolism Research: JaSPER. URL http://jasper.gr.jp/

    Google Scholar 

  6. Nakano T, Goldhaber SZ (eds) (1999) Pulmonary embolism. Springer, New York

    Google Scholar 

  7. Kunio S (ed) (2005) Venous thromboembolism. Springer, Tokyo

    Google Scholar 

  8. Editorial Committee on Japanese Guideline for Prevention of Venous Thromboembolism (2004) Japanese guideline for prevention of venous thromboembolism. Medical Front International, Tokyo

    Google Scholar 

  9. Guidelines for the diagnosis, treatment and prevention of pulmonary thromboembolism and deep vein thrombosis (2004) Jpn Circ J 69:1077–1126

    Google Scholar 

  10. Gillum RF (1987) Pulmonary embolism and thrombophlebitis in the United States, 1970–1985. Am Heart J 114:1262–1264

    Article  PubMed  CAS  Google Scholar 

  11. Bell WR, Simon TL (1982) Current status of pulmonary thromboembolic disease: pathophysiology, diagnosis, prevention, and treatment. Am Heart J 103:239–262

    Article  PubMed  CAS  Google Scholar 

  12. Gore I, Hirst AE, Tanaka K (1964) Myocardial infarction and thrombosis. Arch Intern Med 113:323–330

    PubMed  CAS  Google Scholar 

  13. Hasegawa H, Nagata H, Yamauchi M, et al (1981) Statistical status of pulmonary embolism in Japan (II). Jpn J Chest Dis 40:677–681 (in Japanese)

    Google Scholar 

  14. Mieno T, Kitamura S (1989) Incidence of pulmonary thromboembolism in Japan. Kokyu to Junkan 37:923–927 (in Japanese)

    PubMed  CAS  Google Scholar 

  15. Kitajima I, Tachibana S, Hirota Y, et al (1999) The incidence of pulmonary embolism following total hip arthroplasty. Seikei Geka 50:1287–1290 (in Japanese)

    Google Scholar 

  16. Fujita S, Fuji T, Mitsui T, et al (2000) Prospective multicenter study on prevalence of deep vein thrombosis after total hip or total knee arthroplasty. Seikei Geka 51:745–749 (in Japanese)

    Google Scholar 

  17. Mizukami Y, Murai Y, Fukushima Y, et al (1976) Pulmonary thromboembolism in a sequent autopsy series of 200 elders. Kokyu to Junkan 24:979–984 (in Japanese)

    PubMed  CAS  Google Scholar 

  18. Ito S (1982) Clinico-pathological studies on pulmonary thromboembolism. Mie-Igaku 25:586–597 (in Japanese)

    Google Scholar 

  19. Ito M (1991) Pathology of pulmonary embolism. Kokyu to Junkan 39:567–572

    PubMed  CAS  Google Scholar 

  20. Nakamura Y, Yutani C, Imakita M, et al (1996) Pathophysiology of clinicopathological aspect of venous thrombosis and pulmonary thromboembolism. Jpn J Phlebol 7:17–22 (in Japanese)

    Google Scholar 

  21. Kumasaka N, Sakuma M, Shirato K (1999) Incidence of pulmonary thromboembolism in Japan. Jpn Circ J 63:439–441

    Article  PubMed  CAS  Google Scholar 

  22. Kitamukai O, Sakuma M, Takahashi T, et al (2003) Incidence and characteristics of pulmonary thromboembolism in Japan 2000. Intern Med 42:1090–1094

    Article  PubMed  Google Scholar 

  23. Thomas WA, Davies JNP, O’Neal RM, et al (1960) Incidence of myocardial infarction correlated with venous and pulmonary thrombosis and embolism: a geographic study based on autopsies in Uganda, East Africa and St. Louis, USA. Am J Cardiol 5:4–47

    Google Scholar 

  24. Joffe SN (1974) Racial incidence of postoperative deep vein thrombosis in South Africa. Br J Surg 61:982–983

    Article  PubMed  CAS  Google Scholar 

  25. Dahlback B, Carlsson M, Svensson PJ (1993) Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A 90:1004–1008

    Article  PubMed  CAS  Google Scholar 

  26. Seki T, Okayama H, Kumagai T, et al (1998) Arg506Gln mutation of the coagulation factor V gene not detected in Japanese pulmonary thromboembolism. Heart Vessels 13:195–198

    Article  PubMed  CAS  Google Scholar 

  27. Ro A, Hara M, Takada A (1999) The factor V Leiden mutation and the prothrombin G20210A mutation was not found in Japanese patients with pulmonary thromboembolism. Thromb Haemost 82:1769

    PubMed  CAS  Google Scholar 

  28. White RH, Zhou H, Romano PS (1998) Incidence of idiopathic deep venous thrombosis and secondary thromboembolism among ethnic groups in California. Ann Intern Med 128:737–740

    PubMed  CAS  Google Scholar 

  29. Klatsky AL, Armstrong MA, Poggi J (2000) Risk of pulmonary embolism and/or deep venous thrombosis in Asian-Americans. Am J Cardiol 85:1334–1337

    Article  PubMed  CAS  Google Scholar 

  30. Yamada N, Nakamura M, Ishikura K (2003) Epidemiological characteristics of acute pulmonary thromboembolism in Japan. Int Angiol 22:50–54

    PubMed  CAS  Google Scholar 

  31. Lilienfeld DE (2000) Decreasing mortality from pulmonary embolism in the United States, 1979–1996. Int J Epidemiol 29:465–469

    Article  PubMed  CAS  Google Scholar 

  32. Sakuma M, Konno Y, Shirato K (2002) Increasing mortality from pulmonary embolism in Japan, 1951–2000. Circ J 66:1144–1149

    Article  PubMed  Google Scholar 

  33. Sakuma M, Takahashi T, Kitamukai O, et al (2002) Incidence of pulmonary embolism in Japan: analysis using “Annual of the pathological autopsy cases in Japan.” Ther Res 23:632–634

    Google Scholar 

  34. Nakamura M, Fujioka H, Yamada N, et al (2001) Clinical characteristics of acute pulmonary thromboembolism in Japan: results of a multicenter registry in the Japanese Society of Pulmonary Embolism Research. Clin Cardiol 24:132–138

    Article  PubMed  CAS  Google Scholar 

  35. Sakuma M, Nakamura M, Nakanishi N, et al (2004) Inferior vena cava filter is a new additional therapeutic option to reduce mortality from acute pulmonary embolism. Circ J 68:816–821

    Article  PubMed  Google Scholar 

  36. Ota M, Nakamura M, Yamada N, et al (2002) Prognostic significance of early diagnosis in acute pulmonary thromboembolism with circulatory failure. Heart Vessels 17:7–11

    Article  PubMed  Google Scholar 

  37. Sakuma M, Okada O, Nakamura M, et al (2003) Recent developments in diagnostic imaging techniques and management for acute pulmonary embolism: multicenter registry by the Japanese Society of Pulmonary Embolism Research. Intern Med 42: 470–476

    Article  PubMed  Google Scholar 

  38. Nakamura M, Nakanishi N, Yamada N, et al (2005) Effectiveness and safety of the thrombolytic therapy for acute pulmonary thromboembolism: results of a multicenter registry in the Japanese Society of Pulmonary Embolism Research. Int J Cardiol 99:83–89

    Article  PubMed  Google Scholar 

  39. Wan S, Quinlan DJ, Agnelli G, et al (2004) Thrombolysis compared with heparin for the initial treatment of pulmonary embolism: a meta-analysis of the randomized controlled trials. Circulation 110:744–749

    Article  PubMed  CAS  Google Scholar 

  40. Konstantinides S, Geibel A, Heusel G, et al (2002) Management strategies and prognosis of Pulmonary Embolism-3 Trial investigators: heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. N Engl J Med 347:1143–1150

    Article  PubMed  CAS  Google Scholar 

  41. Yamada N, Ishikura K, Ota S, et al (2006) Pulse-spray pharmacomechanical thrombolysis for proximal deep vein thrombosis. Eur J Vasc Endovasc Surg 31:204–211

    Article  PubMed  CAS  Google Scholar 

  42. Yazu T, Fujioka H, Nakamura M, et al (2000) Long-term results of inferior vena cava filters: experiences in a Japanese population. Intern Med 39:707–714

    Article  PubMed  CAS  Google Scholar 

  43. Decousus H, Leizorovicz A, Parent F, et al (1998) A clinical trial of vena cava filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis. N Engl J Med 338:409–415

    Article  PubMed  CAS  Google Scholar 

  44. Yamada N, Niwa A, Sakuma M, et al (2001) Status of use of temporary vena cava filters in Japan. Ther Res 22:1439–1441 (in Japanese)

    Google Scholar 

  45. Ishikura K, Yamada N, Oota M, et al (2002) Clinical experience with retrievable vena cava filters for prevention of pulmonary thromboembolism. J Cardiol 40:267–273 (in Japanese)

    PubMed  Google Scholar 

  46. Samama MM, Cohen AT, Darmon JY, et al (1999) A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients: prophylaxis in medical patients with Enoxaparin Study Group. N Engl J Med 341: 793–800

    Article  PubMed  CAS  Google Scholar 

  47. Eriksson BI, Bauer KA, Lassen MR, et al (2001) Steering Committee of the Pentasaccharide in Hip-Fracture Surgery Study: fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery. N Engl J Med 345:1298–1304

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Clinical Medicine and Biomedical Science, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Mashio Nakamura, Takeshi Nakano, Satoshi Ota, Norikazu Yamada, Masatoshi Miyahara, Naoki Isaka & Masaaki Ito

Authors
  1. Mashio Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takeshi Nakano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Satoshi Ota
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Norikazu Yamada
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Masatoshi Miyahara
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Naoki Isaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Masaaki Ito
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pathology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Kenzo Tanaka M.D., Ph.D. (Professor Emeritus) (Professor Emeritus)

  2. Department of Biochemistry, University of Washington, J317 Health Science Center, Box 357350, Seattle, WA, 98195, USA

    Earl W. Davie Ph.D. (Professor) (Professor)

  3. School of Medicine, Internal Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Yasuo Ikeda M.D., Ph.D. (Professor) (Professor)

  4. Department of Biology, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan

    Sadaaki Iwanaga Ph.D. (Professor Emeritus) (Professor Emeritus)

  5. Department of Medicine, Nagoya University, 26 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Hidehiko Saito M.D., Ph.D. (Professor Emeritus) (Professor Emeritus)

  6. Pathophysiological and Experimental Division, Department of Pathology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Katsuo Sueishi M.D., Ph.D. (Professor) (Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer

About this chapter

Cite this chapter

Nakamura, M. et al. (2008). Current Clinical Status of Venous Thromboembolism in Japan. In: Tanaka, K., Davie, E.W., Ikeda, Y., Iwanaga, S., Saito, H., Sueishi, K. (eds) Recent Advances in Thrombosis and Hemostasis 2008. Springer, Tokyo. https://doi.org/10.1007/978-4-431-78847-8_38

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-78847-8_38

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-78846-1

  • Online ISBN: 978-4-431-78847-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation