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A Linkage in the Developmental Pathway of Vascular and Hematopoietic Cells

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Recent Advances in Thrombosis and Hemostasis 2008

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Abstract

Blood vessels consist of at least three kinds of cell: endothelial cells lining the inside of the lumen to form tubes, mural cells (vascular smooth muscle cells and pericytes) supporting the endothelial tubes, and blood cells flowing inside. Blood and vascular cells are closely related to each other in their anatomical locations, origins, and differentiation processes. In addition to a long history of histological analyses, recent progress in stem cell biology using various genetic animal models, especially in vivo cell tracing technologies, and in vitro stem cell differentiation systems are now succeeding in providing molecular and cellular bases of the relation between these two cell populations. Accumulating data suggest that their differentiation processes are more complicated than was previously expected. That is, multiple origins of progenitor cells, multiple pathways of differentiation, and multiple molecular functions regulating cell fates exist and complicatedly interact with each other to complete the functional circulation system with blood and vessels. This chapter summarizes recent advances in the developmental processes and the relation of blood and vascular cells, especially between blood and endothelial cells.

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Authors and Affiliations

  1. Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan

    Jun K. Yamashita

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  1. Jun K. Yamashita
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Editors and Affiliations

  1. Department of Pathology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Kenzo Tanaka M.D., Ph.D. (Professor Emeritus) (Professor Emeritus)

  2. Department of Biochemistry, University of Washington, J317 Health Science Center, Box 357350, Seattle, WA, 98195, USA

    Earl W. Davie Ph.D. (Professor) (Professor)

  3. School of Medicine, Internal Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Yasuo Ikeda M.D., Ph.D. (Professor) (Professor)

  4. Department of Biology, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan

    Sadaaki Iwanaga Ph.D. (Professor Emeritus) (Professor Emeritus)

  5. Department of Medicine, Nagoya University, 26 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Hidehiko Saito M.D., Ph.D. (Professor Emeritus) (Professor Emeritus)

  6. Pathophysiological and Experimental Division, Department of Pathology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Katsuo Sueishi M.D., Ph.D. (Professor) (Professor)

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Yamashita, J.K. (2008). A Linkage in the Developmental Pathway of Vascular and Hematopoietic Cells. In: Tanaka, K., Davie, E.W., Ikeda, Y., Iwanaga, S., Saito, H., Sueishi, K. (eds) Recent Advances in Thrombosis and Hemostasis 2008. Springer, Tokyo. https://doi.org/10.1007/978-4-431-78847-8_26

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  • DOI: https://doi.org/10.1007/978-4-431-78847-8_26

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