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Efficient Synthesis of Oligosaccharides and Synthesis of Pathogen-Associated Molecular Patterns for Their Biofunctional Studies

  • Koichi Fukase
  • Yukari Fujimoto
  • Katsunori Tanaka

Abstract

Many natural oligosaccharides and glycoconjugates exist in heterogeneous mixtures that are difficult to isolate. Even if the purification is possible, only small amounts are obtained in general. The recent development of oligosaccharide and glycoconjugate synthesis enables the preparation of complex natural oligosaccharides. Synthetic oligosaccharides and glycoconjugates are now used to study their roles in various biologically important processes. In this section, preparation of bacterial glycoconjugate libraries and their use in biofunctional studies are described.

Keywords

Crown Ether Barbituric Acid Muramyl Dipeptide Muramic Acid Oligosaccharide Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Fukase K, Zhang S-Q, Fukase Y, Umesako N, Kusumoto S (2005a) Synthesis based on affinity separation: a new methodology for high throughput synthesis using affinity tags. ACS Symp Ser 892:87–98CrossRefGoogle Scholar
  2. Fukase K, Takashina M, Hori Y, Tanaka D, Tanaka K, Kusumoto S (2005b) Oligosaccharide synthesis by affinity separation based on molecular recognition between podand ether and ammonium ion. Synlett 2342–2346Google Scholar
  3. Inamura S, Fujimoto Y, Kawasaki A, Shiokawa Z, Woelk E, Heine H, Lindner B, Inohara N, Kusumoto S, Fukase K (2006) Synthesis of peptidoglycan fragments and evaluation of their biological activity. Org Biomol Chem 4:232–242PubMedCrossRefGoogle Scholar
  4. Kusumoto S, Fukase K (2006) Synthesis of endotoxic principle of bacterial lipopolysaccharide and its recognition by the innate immune systems of hosts. Chem Rec 6:333–343PubMedCrossRefGoogle Scholar
  5. Park JW, Je B-R, Piao S, Inamura S, Fujimoto Y, Fukase K, Kusumoto S, Soederhaell K, Ha N-C, Lee BL (2006) A synthetic peptidoglycan fragment as a competitive inhibitor of the melanization cascade. J Biol Chem 281:7747–7755PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Koichi Fukase
    • 1
  • Yukari Fujimoto
    • 1
  • Katsunori Tanaka
    • 1
  1. 1.Department of Chemistry, Graduate School of ScienceOsaka UniversityToyonaka, OsakaJapan

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