Abstract
Many natural oligosaccharides and glycoconjugates exist in heterogeneous mixtures that are difficult to isolate. Even if the purification is possible, only small amounts are obtained in general. The recent development of oligosaccharide and glycoconjugate synthesis enables the preparation of complex natural oligosaccharides. Synthetic oligosaccharides and glycoconjugates are now used to study their roles in various biologically important processes. In this section, preparation of bacterial glycoconjugate libraries and their use in biofunctional studies are described.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fukase K, Zhang S-Q, Fukase Y, Umesako N, Kusumoto S (2005a) Synthesis based on affinity separation: a new methodology for high throughput synthesis using affinity tags. ACS Symp Ser 892:87–98
Fukase K, Takashina M, Hori Y, Tanaka D, Tanaka K, Kusumoto S (2005b) Oligosaccharide synthesis by affinity separation based on molecular recognition between podand ether and ammonium ion. Synlett 2342–2346
Inamura S, Fujimoto Y, Kawasaki A, Shiokawa Z, Woelk E, Heine H, Lindner B, Inohara N, Kusumoto S, Fukase K (2006) Synthesis of peptidoglycan fragments and evaluation of their biological activity. Org Biomol Chem 4:232–242
Kusumoto S, Fukase K (2006) Synthesis of endotoxic principle of bacterial lipopolysaccharide and its recognition by the innate immune systems of hosts. Chem Rec 6:333–343
Park JW, Je B-R, Piao S, Inamura S, Fujimoto Y, Fukase K, Kusumoto S, Soederhaell K, Ha N-C, Lee BL (2006) A synthetic peptidoglycan fragment as a competitive inhibitor of the melanization cascade. J Biol Chem 281:7747–7755
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer
About this chapter
Cite this chapter
Fukase, K., Fujimoto, Y., Tanaka, K. (2008). Efficient Synthesis of Oligosaccharides and Synthesis of Pathogen-Associated Molecular Patterns for Their Biofunctional Studies. In: Taniguchi, N., Suzuki, A., Ito, Y., Narimatsu, H., Kawasaki, T., Hase, S. (eds) Experimental Glycoscience. Springer, Tokyo. https://doi.org/10.1007/978-4-431-77924-7_51
Download citation
DOI: https://doi.org/10.1007/978-4-431-77924-7_51
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-77923-0
Online ISBN: 978-4-431-77924-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)