Synthesis of Glycolipid and Its Application

  • Hideharu Ishida
  • Makoto Kiso


Glycolipids constitute a group of bio-active glycoconjugates along with glycoproteins and proteoglycans. The synthesis of glycolipids by chemical methods is the most reliable procedure because of microheterogeniety carried mainly by lipid moiety, demonstrating good contrast to glycoproteins which are focused on homogeneity, now being synthesized by solid-phase, automated procedure in part.


Sialic Acid Tetanus Toxin Reliable Procedure Membrane Raft Lipid Moiety 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Ando H, Imamura A (2004) Proceeding in synthetic chemistry of sialo-glycoside. TIGG 16:293–303Google Scholar
  2. Fotinou C, Emsley P, Black I et al (2001) The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin. J Biol Chem 276:32274–32281PubMedCrossRefGoogle Scholar
  3. Hasegawa A, Ito K, Ishida H et al (1995) Synthesis of sialyl and sulfo Lewis X analogs containing a ceramide or 2-(tetradecyl)hexadecyl residue. J Carbohydr Chem 14:353–368CrossRefGoogle Scholar
  4. Ishida H, Kiso M (2001) Systematic syntheses of gangliosides. TIGG 13:57–64Google Scholar
  5. Van den Berg RJBHN, Korevaar CGN, Overkleeft HS et al (2004) Effective, high-yielding, and stereospecifi c total synthesis of D-erythro-(2R,3S)-sphingosine from D-ribo-(2S,3S,4R)-phytosphingosine. J Org Chem 69:5699–5704PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Hideharu Ishida
    • 1
  • Makoto Kiso
    • 1
  1. 1.Department of Applied Bio-organic ChemistryGifu UniversityGifuJapan

Personalised recommendations