Molecular Modeling of Oligosugar Structures

  • Masaji Ishiguro


Structural data of oligosugars are essential for understanding their functions in molecular recognition in sugar-protein interactions. Further design of sugar mimics and non-sugar derivatives based on three-dimensional structures of oligosugars is one of the most important subjects in drug design.


Aromatic Amino Acid Molecular Recognition Glycosidic Bond Conformational Analysis Molecular Dynamic Calculation 
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  1. Cioci G, Revet A, Koca J et al (2004) Conformational analysis of complex oligosaccharides: the CICADA approach to the uromodulin O-glycans. Carbohydr Res 339:949–959PubMedCrossRefGoogle Scholar
  2. Imberty A, Perez S (2000) Structure, conformation, and dynamics of bioactive oligosaccharides: the theoretical approaches and experimental validations. Chem Rev 100:4567–4588PubMedCrossRefGoogle Scholar
  3. Kakuda S, Shiba T, Ishiguro M et al (2004) Structural basis for acceptor substrate recognition of a human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1. J Biol Chem 279:22693–22703PubMedCrossRefGoogle Scholar
  4. Shiba T, Kakuda S, Ishiguro M et al (2006) Crystal structure of GlcAT-S, a human glucuronyltransferase, involved in the biosynthesis of the HNK-1 carbohydrate epitope. Proteins 65:499–508PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Masaji Ishiguro
    • 1
  1. 1.Division of Computational and Biofunctional ResearchSuntory Institute for Bioorganic ResearchShimamoto, OsakaJapan

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