• Takashi Muramatsu
  • Kenji Uchimura


Molecular cloning has been accomplished for a large number of carbohydrate sulfotransferases. The majority of them are involved in the synthesis of glycosaminoglycans such as heparan sulfate, chondroitin sulfate, and keratan sulfate (Habuchi et al. 2006), whereas some of them play roles in formation of glycans in glycoproteins or glycolipids. Increasing numbers of carbohydrate sulfotransferases have been knocked out in mice to understand the role of sulfate groups more precisely (Table 1). Interestingly, all knockout mice exhibit phenotypes, underlining the physiological importance of carbohydrate sulfation.


Heparan Sulfate Chondroitin Sulfate Keratan Sulfate Renal Agenesis Lymphocyte Homing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer 2008

Authors and Affiliations

  • Takashi Muramatsu
    • 1
  • Kenji Uchimura
    • 2
  1. 1.Department of Health Science, Faculty of Psychological and Physical ScienceAichi Gakuin UniversityNisshin, AichiJapan
  2. 2.Section of Pathophysiology and Neurobiology, Department of Alzheimer’s Disease ResearchNational Institute for Longevity Sciences (NILS)Obu, AichiJapan

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