Molecular cloning has been accomplished for a large number of carbohydrate sulfotransferases. The majority of them are involved in the synthesis of glycosaminoglycans such as heparan sulfate, chondroitin sulfate, and keratan sulfate (Habuchi et al. 2006), whereas some of them play roles in formation of glycans in glycoproteins or glycolipids. Increasing numbers of carbohydrate sulfotransferases have been knocked out in mice to understand the role of sulfate groups more precisely (Table 1). Interestingly, all knockout mice exhibit phenotypes, underlining the physiological importance of carbohydrate sulfation.
KeywordsHeparan Sulfate Chondroitin Sulfate Keratan Sulfate Renal Agenesis Lymphocyte Homing
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