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Glucuronyltransferase (GlcAT-P) Gene-Deficient Mice

  • Ippei Morita
  • Shogo Oka

Abstract

The HNK-1 carbohydrate has a very unique structural feature comprising a sulfated trisaccharide (HSO3-3GlcAβ1-3Galβ1-4GlcNAc-), whose biosynthesis is regulated by two glucuronyltranferases (GlcAT-P and GlcAT-S). The carbohydrate is expressed on a limited number of glycoproteins, such as neural cell adhesion molecule (NCAM), L1, phosphacan and so on, in the nervous system. To elucidate the role of the HNK-1 carbohydrate, we generated and analyzed mice with a targeted deletion of the GlcAT-P gene, which is mainly expressed in the nervous system.

Keywords

Synaptic Plasticity Neural Cell Adhesion Molecule Escape Latency Morris Water Maze Test Stratum Radiatum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Yamamoto S, Oka S, Inoue M, Shimuta M, Manabe T, Takahashi H, Miyamoto M, Asano M, Sakagami J, Sudo K, Iwakura Y, Ono K, Kawasaki T (2002) Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning. J Biol Chem 277:27227–27231PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Ippei Morita
    • 1
  • Shogo Oka
    • 2
  1. 1.Department of Biological Chemistry, Graduate School of Pharmaceutical SciencesKyoto UniversityKyotoJapan
  2. 2.Department of Biological Chemistry, School of Health Sciences, Faculty of MedicineKyoto UniversityKyotoJapan

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