Glucuronyltransferase (GlcAT-P) Gene-Deficient Mice

  • Ippei Morita
  • Shogo Oka


The HNK-1 carbohydrate has a very unique structural feature comprising a sulfated trisaccharide (HSO3-3GlcAβ1-3Galβ1-4GlcNAc-), whose biosynthesis is regulated by two glucuronyltranferases (GlcAT-P and GlcAT-S). The carbohydrate is expressed on a limited number of glycoproteins, such as neural cell adhesion molecule (NCAM), L1, phosphacan and so on, in the nervous system. To elucidate the role of the HNK-1 carbohydrate, we generated and analyzed mice with a targeted deletion of the GlcAT-P gene, which is mainly expressed in the nervous system.


Synaptic Plasticity Neural Cell Adhesion Molecule Escape Latency Morris Water Maze Test Stratum Radiatum 
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  1. Yamamoto S, Oka S, Inoue M, Shimuta M, Manabe T, Takahashi H, Miyamoto M, Asano M, Sakagami J, Sudo K, Iwakura Y, Ono K, Kawasaki T (2002) Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning. J Biol Chem 277:27227–27231PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Ippei Morita
    • 1
  • Shogo Oka
    • 2
  1. 1.Department of Biological Chemistry, Graduate School of Pharmaceutical SciencesKyoto UniversityKyotoJapan
  2. 2.Department of Biological Chemistry, School of Health Sciences, Faculty of MedicineKyoto UniversityKyotoJapan

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