Knockout Mice of α1,6 Fucosyltransferase (Fut 8)

  • Naoyuki Taniguchi


The core fucosylation (α1,6-fucosylation) of glycoproteins is widely distributed in mammalian tissues, and is altered under pathological conditions. To investigate the physiological functions of the core fucose, we generated α1,6-fucosyltransferase (Fut8)-null mice and found that disruption of Fut8 induces severe growth retardation and death during postnatal development. Histopathological analysis revealed that Fut8 -/- mice showed emphysema-like changes in the lung, verified by a physiological compliance analysis.


Acinar Cell Carcinoma Postnatal Development Severe Growth Retardation Curr Opin Struct Biol Mouse Pancreatic Acinar Cell 
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Copyright information

© Springer 2008

Authors and Affiliations

  • Naoyuki Taniguchi
    • 1
    • 2
  1. 1.Department of Disease Glycomics (Seikagaku Corporation), Institute for Microbial DiseasesOsaka UniversityOsakaJapan
  2. 2.Disease Glycomics Team, Systems Glycobiology Research Group, Chemical Biology DepartmentAdvanced Science Institute, RIKENWakoJapan

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