Fucosyltransferase (α1,2/ α1,3/ α1,4-fucosyltransferases)

  • Takashi Kudo
  • Hisashi Narimatsu


Many studies using monoclonal antibodies have demonstrated that fucosylated carbohydrate chains are involved in various physiological functions including development, neuronal activity, and cancerous transformation. The genes encoding fucosyltransferases which synthesize fucosylated carbohydrate antigens have been cloned, and their function has been gradually elucidated by analyses of their substrate specificities and biological functions (Taniguchi et al. 2002).


Carbohydrate Chain Blood Group Antigen System Blood Group Cancerous Transformation Lewis Blood Group 
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  1. Homeister JW, Thall AD et al (2001) The α(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. Immunity 15:115–126PubMedCrossRefGoogle Scholar
  2. Kudo T, Kaneko M et al (2004) Normal embryonic and germ cell development in mice lacking α1,3-fucosyltransferase IX (Fut9) which show disappearance of stage-specific embryonic antigen 1. Mol Cell Biol 24:4221–4228PubMedCrossRefGoogle Scholar
  3. Narimatsu H, Iwasaki H et al (1998) Lewis and secretor gene dosages affect CA19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients. Cancer Res 58:512–518PubMedGoogle Scholar
  4. Nishihara S, Hiraga T et al (1999) Molecular behavior of mutant Lewis enzymes in vivo. Glycobiology 9:373–382PubMedCrossRefGoogle Scholar
  5. Taniguchi N, Honke K, Fukuda M (eds) (2002) Handbook of glycosyltransferases and related genes. Springer, TokyoGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Takashi Kudo
    • 1
  • Hisashi Narimatsu
    • 2
  1. 1.Graduate School of Comprehensive Human SciencesUniversity of TsukubaTsukuba, IbarakiJapan
  2. 2.Research Center for Medical GlycosciencesNational Institute of Advanced Industrial Science and Technology (AIST)Tsukuba, IbarakiJapan

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