Fucosyltransferase-9 Knockout Mouse

  • Takashi Kudo
  • Hisashi Narimatsu


Stage-specific embryonic antigen-1 (SSEA-1), an antigenic epitope of which was defined as a Lewis x [Lex: Galβ1–4(Fucα1–3)GlcNAc-] carbohydrate structure, is widely expressed on the surface of mammalian cells, and is considered to be involved in cell-cell interactions during embryogenesis, differentiation, and neurodevelopmental processes. FUT3, FUT4, FUT5, FUT6 and FUT9 can synthesize the Lex structure, while FUT7 cannot (Kudo et al. 1998). Detailed analysis of the substrate specificity of polylactosamine acceptor has revealed FUT9 to have more-efficient activity for synthesis of the Lex structure than other α1,3FUTs (Nishihara et al. 1999).


Carbohydrate Structure GlcNAc Residue Neurodevelopmental Process Develop Mouse Embryo Amine Acceptor 
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  1. Kudo T, Ikehara Y et al (1998) Expression cloning and characterization of a novel murine α1,3-fucosyltransferase, mFuc-TIX, that synthesizes the Lewis x (CD15) epitope in brain and kidney. J Biol Chem 273:26729–26738PubMedCrossRefGoogle Scholar
  2. Kudo T, Kaneko M et al (2004) Normal embryonic and germ cell development in mice lacking α1,3-fucosyltransferase IX (Fut9) which show disappearance of stage-specific embryonic antigen 1. Mol Cell Biol 24:4221–4228PubMedCrossRefGoogle Scholar
  3. Kudo T, Fujii T et al (2007) Mice lacking α1,3-fucosyltransferase IX demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors. Glycobiology 17:1–9PubMedCrossRefGoogle Scholar
  4. Nishihara S, Iwasaki H et al (1999) α1,3-Fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four α1,3FUT members preferentially fucosylate the inner GlcNAc residue. FEBS Lett 462:289–294PubMedCrossRefGoogle Scholar
  5. Nishihara S, Iwasaki H et al (2003) α1,3-Fucosyltransferase IX (Fut9) determines Lewis X expression in brain. Glycobiology 13:445–455PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Takashi Kudo
    • 1
  • Hisashi Narimatsu
    • 2
  1. 1.Graduate School of Comprehensive Human SciencesUniversity of TsukubaTsukuba, IbarakiJapan
  2. 2.Research Center for Medical GlycosciencesNational Institute of Advanced Industrial Science and Technology (AIST)Tsukuba, IbarakiJapan

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