The Midkine Family and Its Receptors

  • Kenji Kadomatsu


Midkine (MK) and pleiotrophin (PTN) comprise a family, the MK family, which is distinct from other growth factor families. The MK family is evolutionally conserved, and it is studied in a variety of animals. The C-terminal domain of MK contains cluster I, a cluster of basic amino acids. Cluster I is important for binding to heparin and chondroitin sulfate.


Sodium Chloride Heparan Sulfate Chondroitin Sulfate Anaplastic Lymphoma Kinase Protein Tyrosine Phosphatase 
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  1. Kadomatsu K, Muramatsu T (2004) Midkine and pleiotrophin in neural development and cancer. Cancer Lett 204:127–143PubMedCrossRefGoogle Scholar

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© Springer 2008

Authors and Affiliations

  • Kenji Kadomatsu
    • 1
  1. 1.Department of BiochemistryNagoya University Graduate School of MedicineNagoyaJapan

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