The Midkine Family and Its Receptors

Kadomatsu, Kenji

doi:10.1007/978-4-431-77922-3_84

Kenji Kadomatsu⁸

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Abstract

Midkine (MK) and pleiotrophin (PTN) comprise a family, the MK family, which is distinct from other growth factor families. The MK family is evolutionally conserved, and it is studied in a variety of animals. The C-terminal domain of MK contains cluster I, a cluster of basic amino acids. Cluster I is important for binding to heparin and chondroitin sulfate.

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Reference

Kadomatsu K, Muramatsu T (2004) Midkine and pleiotrophin in neural development and cancer. Cancer Lett 204:127–143
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Authors and Affiliations

Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
Kenji Kadomatsu

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Kenji Kadomatsu
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Editors and Affiliations

Department of Disease Glycomics, Research Institute for Microbial Diseases, Osaka University, 1-1 Yamadaoka, Suita, Osaka, 565-0871, Japan
Naoyuki Taniguchi M.D., Ph.D. (Professor) (Professor)
Systems Glycobiology Group, Advanced Science Institute, RIKEN, Wako, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan
Naoyuki Taniguchi M.D., Ph.D. (Professor) (Professor)
Institute of Glycotechnology, Future Science and Technology Joint Research Center, Tokai University, Hiratsuka, Kanagawa, 259-1292, Japan
Akemi Suzuki M.D., Ph.D. (Professor) (Professor)
Synthetic Cellular Chemistry Laboratory, RIKEN Discovery Research Institute, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan
Yukishige Ito Ph.D. (Chief Researcher) (Chief Researcher)
Research Center for Medical Glycoscience, Advanced Industrial Science and Technology, AIST Tsukuba, Central 2, Tsukuba, Ibaraki, 305-8568, Japan
Hisashi Narimatsu M.D., Ph.D.
Research Center for Glycobiotechnology, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga, 525-8577, Japan
Toshisuke Kawasaki Ph.D. (Professor) (Professor)
Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan
Sumihiro Hase Ph.D. (Professor) (Professor)

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Kadomatsu, K. (2008). The Midkine Family and Its Receptors. In: Taniguchi, N., Suzuki, A., Ito, Y., Narimatsu, H., Kawasaki, T., Hase, S. (eds) Experimental Glycoscience. Springer, Tokyo. https://doi.org/10.1007/978-4-431-77922-3_84

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DOI: https://doi.org/10.1007/978-4-431-77922-3_84
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-77921-6
Online ISBN: 978-4-431-77922-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

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