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Studies on Functions of Notch O-Fucosylation in Drosophila

  • Tomonori Ayukawa
  • Kenji Matsuno

Abstract

Notch signaling is an evolutionarily conserved mechanism that regulates a broad spectrum of cell-specification events through local cell-cell communication. Notch encodes a single-pass transmembrane receptor protein with 36 epidermal growth factor-like (EGF) repeats. The EGF-like repeats of the Notch extracellular domain, which contain a consensus sequence, are modified by the O-linked tetrasaccharide Sia-α2,3-Gal-β1,4-GlcNAc-β1,3-Fuc (Fig. 1A). A GDP-fucose protein O-fucosyltransferase1 catalyzes this O-linked fucosylation (Wang et al. 2001). In Drosophila, this enzyme is encoded by O-fut1.

Keywords

Notch Signaling Mutant Embryo Wing Disc Aleuria Aurantia Lectin Salt Monohydrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer 2008

Authors and Affiliations

  • Tomonori Ayukawa
    • 1
  • Kenji Matsuno
    • 1
  1. 1.Department of Biological Science and TechnologyTokyo University of ScienceNoda, ChibaJapan

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