Glycoconjugates in Spermatogenesis

  • Koichi Honke


Spermatogenesis occurs in the seminiferous tubules in the testis. Spermatogonia that are germline stem cells sit in a special place on the basement membrane of seminiferous tubules called niche. These spermatogonial stem cells differentiate into spermatocytes, ceasing proliferation. Subsequently, spermatocytes undergo meiosis and differentiate into haploid cells referred to as spermatids, migrating from the surrounding to the lumen of the seminiferous tubules on the stroma cells termed Sertoli cells with mutual interaction. After that, they mature into spermatozoa via morphogenesis and leave the seminiferous tubules for epididymis through the efferent ductules.


Germ Cell Sertoli Cell Leydig Cell Seminiferous Tubule Spermatogonial Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Akama TO, Nakagawa H, Sugihara K, Narisawa S, Ohyama C, Nishimura S, O’Brien DA, Moremen KW, Millan JL, Fukuda MN (2002) Germ cell survival through carbohydrate-mediated interaction with Sertoli cells. Science 295:124–127PubMedCrossRefGoogle Scholar
  2. Fujimoto H, Tadano-Aritomi K, Tokumasu A, Ito K, Hikita T, Suzuki K, Ishizuka I (2000) Requirement of seminolipid in spermatogenesis revealed by UDP-galactose: ceramide galactosyltransferase-deficient mice. J Biol Chem 275:22623–22626PubMedCrossRefGoogle Scholar
  3. Honke K, Hirahara Y, Dupree J, Suzuki K, Popko B, Fukushima K, Fukushima J, Nagasawa T, Yoshida N, Wada Y, Taniguchi N (2002) Paranodal junction formation and spermatogenesis require sulfoglycolipids. Proc Natl Acad Sci USA 99:4227–4232PubMedCrossRefGoogle Scholar
  4. Ishizuka I (1997) Chemistry and functional distribution of sulfoglycolipids. Prog Lipid Res 36:245–319PubMedCrossRefGoogle Scholar
  5. Takamiya K, Yamamoto A, Furukawa K, Zhao J, Fukumoto S, Yamashiro S, Okada M, Haraguchi M, Shin M, Kishikawa M, Shiku H, Aizawa S, Furukawa K (1998) Complex gangliosides are essential in spermatogenesis of mice: possible roles in the transport of testosterone. Proc Natl Acad Sci USA 95:12147–12152PubMedCrossRefGoogle Scholar
  6. Vos JP, Lopes-Cardozo M, Gadella BM (1994) Metabolic and functional aspects of sulfogalactolipids. Biochim Biophys Acta 1211:125–149 (review)PubMedGoogle Scholar
  7. Zhang Y, Hayashi Y, Cheng X, Watanabe T, Wang X, Taniguchi N, Honke K (2005) Testis-specific sulfoglycolipid, seminolipid is essential for germ cell function in spermatogenesis. Glycobiology 15:649–654PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Koichi Honke
    • 1
    • 2
  1. 1.Department of BiochemistryKochi University Medical SchoolNankoku, KochiJapan
  2. 2.CRESTJapan Science and Technology AgencyJapan

Personalised recommendations