Glycoantigens in Xenotransplantation

  • Shuji Miyagawa


The growing numerical gap between the number of patients and available human donor organs has led to a revival of interest in xenotransplantation. A number of trials are currently underway, especially pig islet transplantation, the aim of which is to develop transgenic and knockout pigs in which hyperacute rejection (HAR) and acute vascular rejection (AVR) can be overcome. These rejections are strongly related to species-specific glycoantigens.


Hyperacute Rejection High Mannose Type Acute Vascular Rejection Terminal Glycosylation Perv Infectivity 


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© Springer 2008

Authors and Affiliations

  • Shuji Miyagawa
    • 1
  1. 1.Division of Organ Transplantation, Department of Molecular TherapeuticsOsaka University Graduate School of MedicineSuita, OsakaJapan

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