Roles of Carbohydrate-Mediated Cell Adhesion in Cancer Progression
It has long been known that malignant transformation is associated with the appearance of abnormal carbohydrate determinants on the cell surface. The monoclonal antibody approach to cancer-associated antigens, which prevailed worldwide in the early 1980s, further facilitated research on carbohydrate determinants, because not a few monoclonal antibodies that had preferential reactivity to cancer cells turned out to recognize carbohydrate determinants. The serum diagnosis of tumors using cancer-associated carbohydrate determinants has been covered by the national medical insurance program in Japan over the past two decades, and is widely accepted by clinicians to be clinically beneficial (Kannagi et al. 2004).
KeywordsSialic Acid Hematogenous Metastasis Normal Epithelial Cell Endometrioid Adenocarcinoma Serous Adenocarcinoma
Unable to display preview. Download preview PDF.
- Izawa M, Kumamoto K, Mitsuoka C, Kanamori A, Ohmori K, Ishida H, Nakamura S, Kurata-Miura K, Sasaki K, Nishi T, Kannagi R (2000) Expression of sialyl 6-sulfo Lewis x is inversely correlated with conventional sialyl Lewis x expression in human colorectal cancer. Cancer Res 60:1410–1416PubMedGoogle Scholar
- Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, Chen J, Kobayashi M, Hosokawa M, Taniguchi A, Kojima T, Ishida N, Kawakita M, Yamamoto H, Takematsu H, Kozutsumi Y, Suzuki A, Kannagi R (2004) Hypoxia induces adhesion molecules on cancer cells—a missing link between Warburg effect and induction of selectin ligand carbohydrates. Proc Natl Acad Sci USA 101:8132–8137PubMedCrossRefGoogle Scholar
- Miyazaki K, Ohmori K, Izawa M, Koike T, Kumamoto K, Furukawa K, Ando T, Kiso M, Yamaji T, Hashimoto Y, Suzuki A, Yoshida A, Takeuchi M, Kannagi R (2004) Loss of disialyl Lewisa, the ligand for lymphocyte inhibitory receptor Siglec-7, associated with increased sialyl Lewisa expression on human colon cancers. Cancer Res 64:4498–4505PubMedCrossRefGoogle Scholar
- Yin J, Hashimoto A, Izawa M, Miyazaki K, Chen G-Y, Takematsu H, Kozutsumi Y, Suzuki A, Furuhata K, Cheng F-L, Lin C-H, Sato C, Kitajima K, Kannagi R (2006) Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing nonhuman sialic acid on human cancer cells. Cancer Res 66:2937–2945PubMedCrossRefGoogle Scholar