Roles of Carbohydrate-Mediated Cell Adhesion in Cancer Progression

  • Reiji Kannagi
  • Akira Seko


It has long been known that malignant transformation is associated with the appearance of abnormal carbohydrate determinants on the cell surface. The monoclonal antibody approach to cancer-associated antigens, which prevailed worldwide in the early 1980s, further facilitated research on carbohydrate determinants, because not a few monoclonal antibodies that had preferential reactivity to cancer cells turned out to recognize carbohydrate determinants. The serum diagnosis of tumors using cancer-associated carbohydrate determinants has been covered by the national medical insurance program in Japan over the past two decades, and is widely accepted by clinicians to be clinically beneficial (Kannagi et al. 2004).


Sialic Acid Hematogenous Metastasis Normal Epithelial Cell Endometrioid Adenocarcinoma Serous Adenocarcinoma 
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  1. Izawa M, Kumamoto K, Mitsuoka C, Kanamori A, Ohmori K, Ishida H, Nakamura S, Kurata-Miura K, Sasaki K, Nishi T, Kannagi R (2000) Expression of sialyl 6-sulfo Lewis x is inversely correlated with conventional sialyl Lewis x expression in human colorectal cancer. Cancer Res 60:1410–1416PubMedGoogle Scholar
  2. Kannagi R (2004) Molecular mechanism for cancer-associated induction of sialyl Lewis X and sialyl Lewis A expression—the Warburg effect revisited. Glycoconj J 20:353–364PubMedCrossRefGoogle Scholar
  3. Kannagi R, Izawa M, Koike T, Miyazaki K, Kimura N (2004) Carbohydrate-mediated cell adhesion in cancer metastasis and angiogenesis. Cancer Sci 95:377–384PubMedCrossRefGoogle Scholar
  4. Kanoh A, Seko A, Ideo H, Yoshida M, Nomoto M, Yonezawa S, Sakamoto M, Kannagi R, Yamashita K (2006) Ectopic expression of N-acetylglucosamine 6-O-sulfotransferase 2 in chemotherapy-resistant ovarian adenocarcinomas. Glycoconj J 23:453–460PubMedCrossRefGoogle Scholar
  5. Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, Chen J, Kobayashi M, Hosokawa M, Taniguchi A, Kojima T, Ishida N, Kawakita M, Yamamoto H, Takematsu H, Kozutsumi Y, Suzuki A, Kannagi R (2004) Hypoxia induces adhesion molecules on cancer cells—a missing link between Warburg effect and induction of selectin ligand carbohydrates. Proc Natl Acad Sci USA 101:8132–8137PubMedCrossRefGoogle Scholar
  6. Miyazaki K, Ohmori K, Izawa M, Koike T, Kumamoto K, Furukawa K, Ando T, Kiso M, Yamaji T, Hashimoto Y, Suzuki A, Yoshida A, Takeuchi M, Kannagi R (2004) Loss of disialyl Lewisa, the ligand for lymphocyte inhibitory receptor Siglec-7, associated with increased sialyl Lewisa expression on human colon cancers. Cancer Res 64:4498–4505PubMedCrossRefGoogle Scholar
  7. Phillips ML, Nudelman E, Gaeta FCA, Perez M, Singhal AK, Hakomori S, Paulson JC (1990) ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. Science 250:1130–1132PubMedCrossRefGoogle Scholar
  8. Takada A, Ohmori K, Takahashi N, Tsuyuoka K, Yago K, Zenita K, Hasegawa A, Kannagi R (1991) Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A. Biochem Biophys Res Commun 179:713–719PubMedCrossRefGoogle Scholar
  9. Yin J, Hashimoto A, Izawa M, Miyazaki K, Chen G-Y, Takematsu H, Kozutsumi Y, Suzuki A, Furuhata K, Cheng F-L, Lin C-H, Sato C, Kitajima K, Kannagi R (2006) Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing nonhuman sialic acid on human cancer cells. Cancer Res 66:2937–2945PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Reiji Kannagi
    • 1
  • Akira Seko
    • 2
  1. 1.Department of Molecular PathologyAichi Cancer CenterAichiJapan
  2. 2.Innovative Research InitiativesTokyo Institute of TechnologyTokyoJapan

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