Regulation of Glycosyltransferases for O-Glycan Core Structure in Cancer and Their Relations to Metastasis

  • Toshie Iwai
  • Hisashi Narimatsu


Synthesis of many O-linked carbohydrate chains (O-glycan) is initiated by transferring GalNAc to the Ser/Thr residue in an amino acid sequence by polypeptide GalNAc transferase (pp-GalNAc-T) (Cheng et al. 2004). These O-glycans are called mucin-type carbohydrate chains, and most of them are found on glycoproteins called mucin. Mucin, which is the major constituent of mucus glycoproteins, not only protects the mucosal membrane from invasion of viruses and chemical substances but also is involved in various biological phenomena including cell adhesion, signal transduction, inflammation, and metastasis.


Sialic Acid Familial Adenomatous Polyposis Carbohydrate Chain Mucus Glycoprotein GalNAc Residue 
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© Springer 2008

Authors and Affiliations

  • Toshie Iwai
    • 1
  • Hisashi Narimatsu
    • 1
  1. 1.Research Center for Medical GlycoscienceNational Institute of Advanced Industrial Science and Technology (AIST)Tsukuba, IbarakiJapan

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