Abstract
Influenza is one of the most widely distributed zoonotic infectious diseases in the world, and its pathogen, the influenza virus, is extremely mutable. Highly pathogenic H5N1 avian influenza viruses have become resident in poultry within Asia, Europe, Africa, and Middle East, and continue to pose a pandemic threat. The poultry infections in East and Central Asia and east Africa since 2004 have led to 380 confirmed cases of human H5N1 disease in 14 countries with 240 deaths until April 15, 2008 (WHO Web). However, the transmission of the virus from poultry to human remains inefficient and human-to-human transmission is so far, an infrequent event.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Auewarakul P, Suptawiwat O, Kongchanagul A, Sangma C, Suzuki Y, Ungchusak K, Louisirirotchanakul S, Lerdsamran H, Pooruk P, Thitithanyanont A, Pittayawonganon C, Guo CT, Hiramatsu H, Jampangern W, Chunsutthiwat S, Puthavathana P (2007) An avian influenza H5N1 virus that binds to a human-type receptor. J Virol 81:9950–9955
Kobasa D, Takada A, Shinya K, Halfman P, Hatta M, Theriault S, Suzuki H, Nishimura H, Mitamura K, Sugaya N, Usui T, Murata T, Suzuki T, Suzuki Y, Feldman H, Kawaoka Y (2004) Enhanced pathogenicity of influenza A viruses possessing the haemagglutinin of the 1918 pandemic. Nature 431:703–707
Le MQ, Kiso M, Someya K, Sakai YT, Nguyen TH, Nguyen KHL, Pham ND, Ngyen HH, Yamada S, Muramoto Y, Horimoto T, Takada A, Goto H, Suzuki T, Suzuki Y, Kawaoka Y (2005) Isolation of drug-resistant H5N1 virus. Nature 437:1108
Suzuki Y (2005) Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses. Biol Pharm Bull 28:399–408
Suzuki Y (2007) The highly pathogenic avian flu viruses and the molecular mechanism of the transmission of the viruses into humans. In: Kamerling H (ed) Comprehensive glycoscience from chemistry to systems biology, November issue. Elsevier Publishing book, Amsterdam pp 465–471
Yamada S, Suzuki Y, Suzuki T, Le MQ, Nidom CA, Sakai YT, Muramoto Y, Ito M, Kiso M, Horimoto T, Shinya K, Sawada T, Kiso M, Lin Y, Hay A, Haire LF, Stevens DJ, Russel RJ, Gambin SJ, Skehel JJ, Kawaoka Y (2006) Hemagglutinin nutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature 444:378–382
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer
About this chapter
Cite this chapter
Suzuki, Y. (2008). Developing an Assay System for the Hemagglutinin Mutations Responsible for the Binding of Highly Pathogenic Avian Influenza A Viruses to Human-Type Receptors. In: Taniguchi, N., Suzuki, A., Ito, Y., Narimatsu, H., Kawasaki, T., Hase, S. (eds) Experimental Glycoscience. Springer, Tokyo. https://doi.org/10.1007/978-4-431-77922-3_54
Download citation
DOI: https://doi.org/10.1007/978-4-431-77922-3_54
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-77921-6
Online ISBN: 978-4-431-77922-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)