Developing an Assay System for the Hemagglutinin Mutations Responsible for the Binding of Highly Pathogenic Avian Influenza A Viruses to Human-Type Receptors
Influenza is one of the most widely distributed zoonotic infectious diseases in the world, and its pathogen, the influenza virus, is extremely mutable. Highly pathogenic H5N1 avian influenza viruses have become resident in poultry within Asia, Europe, Africa, and Middle East, and continue to pose a pandemic threat. The poultry infections in East and Central Asia and east Africa since 2004 have led to 380 confirmed cases of human H5N1 disease in 14 countries with 240 deaths until April 15, 2008 (WHO Web). However, the transmission of the virus from poultry to human remains inefficient and human-to-human transmission is so far, an infrequent event.
KeywordsSialic Acid H5N1 Virus Avian Virus Pathogenic H5N1 Avian H5N1 Virus
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