Developing an Assay System for the Hemagglutinin Mutations Responsible for the Binding of Highly Pathogenic Avian Influenza A Viruses to Human-Type Receptors

  • Yasuo Suzuki


Influenza is one of the most widely distributed zoonotic infectious diseases in the world, and its pathogen, the influenza virus, is extremely mutable. Highly pathogenic H5N1 avian influenza viruses have become resident in poultry within Asia, Europe, Africa, and Middle East, and continue to pose a pandemic threat. The poultry infections in East and Central Asia and east Africa since 2004 have led to 380 confirmed cases of human H5N1 disease in 14 countries with 240 deaths until April 15, 2008 (WHO Web). However, the transmission of the virus from poultry to human remains inefficient and human-to-human transmission is so far, an infrequent event.


Sialic Acid H5N1 Virus Avian Virus Pathogenic H5N1 Avian H5N1 Virus 
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  1. Auewarakul P, Suptawiwat O, Kongchanagul A, Sangma C, Suzuki Y, Ungchusak K, Louisirirotchanakul S, Lerdsamran H, Pooruk P, Thitithanyanont A, Pittayawonganon C, Guo CT, Hiramatsu H, Jampangern W, Chunsutthiwat S, Puthavathana P (2007) An avian influenza H5N1 virus that binds to a human-type receptor. J Virol 81:9950–9955PubMedCrossRefGoogle Scholar
  2. Kobasa D, Takada A, Shinya K, Halfman P, Hatta M, Theriault S, Suzuki H, Nishimura H, Mitamura K, Sugaya N, Usui T, Murata T, Suzuki T, Suzuki Y, Feldman H, Kawaoka Y (2004) Enhanced pathogenicity of influenza A viruses possessing the haemagglutinin of the 1918 pandemic. Nature 431:703–707PubMedCrossRefGoogle Scholar
  3. Le MQ, Kiso M, Someya K, Sakai YT, Nguyen TH, Nguyen KHL, Pham ND, Ngyen HH, Yamada S, Muramoto Y, Horimoto T, Takada A, Goto H, Suzuki T, Suzuki Y, Kawaoka Y (2005) Isolation of drug-resistant H5N1 virus. Nature 437:1108PubMedCrossRefGoogle Scholar
  4. Suzuki Y (2005) Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses. Biol Pharm Bull 28:399–408PubMedCrossRefGoogle Scholar
  5. Suzuki Y (2007) The highly pathogenic avian flu viruses and the molecular mechanism of the transmission of the viruses into humans. In: Kamerling H (ed) Comprehensive glycoscience from chemistry to systems biology, November issue. Elsevier Publishing book, Amsterdam pp 465–471Google Scholar
  6. Yamada S, Suzuki Y, Suzuki T, Le MQ, Nidom CA, Sakai YT, Muramoto Y, Ito M, Kiso M, Horimoto T, Shinya K, Sawada T, Kiso M, Lin Y, Hay A, Haire LF, Stevens DJ, Russel RJ, Gambin SJ, Skehel JJ, Kawaoka Y (2006) Hemagglutinin nutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature 444:378–382PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Yasuo Suzuki
    • 1
  1. 1.Department of Biomedical Sciences, College of Life and Health SciencesChubu UniversityKasugai, AichiJapan

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