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Retrograde Transport of Glycolipid-Bound Toxins

  • Ryo Misaki
  • Tomohiko Taguchi

Abstract

Cholera toxin (CTX) produced by Vibrio cholerae is the virulence factor responsible for the massive secretory diarrhea. It belongs to the AB5-subunit family of toxins. Five identical 11-kDa peptides (B-subunit) form a ring-like structure, through the hole of which A-subunit protrudes. The B-subunit is a lectin which binds to GM1 at the plasma membrane, whereas the A-subunit is an ADP-ribosyltransferase that can activate Gsα (heterotrimeric G protein). Other toxins, such as Shiga toxin (STX), bind other glycolipids, e.g., Gb3.

Keywords

Cholera Toxin Golgi Complex Early Endosome Late Endosome Retrograde Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer 2008

Authors and Affiliations

  • Ryo Misaki
    • 1
  • Tomohiko Taguchi
    • 1
  1. 1.Department of BiochemistryOsaka University School of MedicineOsakaJapan

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