Retrograde Transport of Glycolipid-Bound Toxins
Cholera toxin (CTX) produced by Vibrio cholerae is the virulence factor responsible for the massive secretory diarrhea. It belongs to the AB5-subunit family of toxins. Five identical 11-kDa peptides (B-subunit) form a ring-like structure, through the hole of which A-subunit protrudes. The B-subunit is a lectin which binds to GM1 at the plasma membrane, whereas the A-subunit is an ADP-ribosyltransferase that can activate Gsα (heterotrimeric G protein). Other toxins, such as Shiga toxin (STX), bind other glycolipids, e.g., Gb3.
KeywordsCholera Toxin Golgi Complex Early Endosome Late Endosome Retrograde Transport
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